Ep 17 Assoc Prof Jason Tye-Din on Coeliac Disease

Talking Gut with Dr Jim Kantidakis

Dr Tye-Din is a gastroenterologist with a clinical and research interest in Coeliac disease. He heads the Coeliac Research Lab at the Walter and Eliza Hall Institute, runs a Coeliac clinic at the Royal Melbourne Hospital and is an Honorary Research Fellow at the Murdoch Children’s Research Institute. His PhD employed feeding studies to characterise gluten immunity that underpinned development of a novel immunotherapy for Coeliac disease, Nexvax2.

His research interests include understanding the immune and genetic basis for coeliac disease and how gluten tolerance is lost, the role of the microbiome, understanding why the gluten-free diet can fail, and developing and testing novel diagnostics and treatments. He is on the editorial board of Alimentary Pharmacology and Therapeutics and consults for an industry partner (ImmusanT Inc.) who are leading the development of Nexvax2. Jason chairs the Medical Advisory Committee of Coeliac Australia and is involved in patient advocacy, clinical guideline development and medical education.

In todays talk, we covered a lot. There was so much about coeliac disease that I didn’t know, and so, I think a lot of people, medical professionals as well as individuals managing this disease, will find this episode really interesting and helpful.

So what did we cover?

We talked about

1. What Coeliac disease is?
2. Its Incidence and prevalence ?
3. Age of onset ?
4. What the symptoms are ?
5. The potential complications of undiagnosed untreated coeliac disease?
6. Why a gluten free diet may sometimes be unsuccessful in reducing complications
7. The different ways to diagnose Coeliac disease?
8. Why Coeliac disease can be under diagnosed
9. The overlap between Coeliac disease and functional gut disorders
10. The difference between Coeliac disease and Non-Coeliac Gluten Hypersensitivity
11. We also talking about his exciting new research in developing a vaccine, called the Nexvax2
12. We talked about the research looking at utilising the hook worm to manage the disease
13. What is important for a person managing Coeliac disease or newly diagnosed to know?
14. What would be take home message for health professionals ?

and...a whole lot more...

Please enjoy my conversation with Dr Jason Tye-Din