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Lithium Toxicity
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When? This feed was archived on March 22, 2023 20:11 (). Last successful fetch was on February 16, 2023 22:11 ()
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Manage episode 346928048 series 2811669
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Lithium Toxicity
Dr Swapnil Pawar
Lithium Toxicity
Written by Dr Andrew Lam
Interpretation of Lithium Levels
Therapeutic level – 0.8 – 1.2mmol/L
Mild Toxicity – 1.5 – 2.5mmol/L
Moderate to Severe Toxicity from – 2.5 – 3.5mmol/L
Severe toxicity – >3.5mmol/L
Symptoms of Toxicity
Gastrointestinal – nausea, vomiting and diarrhea. (More common in acute toxicity)
Neurological – ataxia, sluggishness, slurred speech, agitation and tremors. In more severe toxicity, can result in seizures and encephalopathy (More common in chronic toxicity)
Cardiovascular – dysrhythmias and cardiovascular collapse (rarer)
Management of Lithium Toxicity
In acute ingestions – whole bowel contamination with polyethylene glycol:
If immediate release lithium – must be given within 1 hour of ingestion
If sustained release lithium – must be given within 4 hours of ingestion
Judicious fluid resuscitation to allow for intrinsic renal elimination
If levels >5mmol/L or >4mmol/L with renal failure or signs of severe toxicity, elimination with haemodialysis is required. Usually, 1 session of intermittent haemodialysis is sufficient. Repeat lithium levels must be taken 6 hours post-dialysis, and if <1mmol/L, dialysis can be ceased.
The post Lithium Toxicity first appeared on Critical Care Education.
32 επεισόδια
Αρχειοθετημένη σειρά ("Ανενεργό feed" status)
When? This feed was archived on March 22, 2023 20:11 (). Last successful fetch was on February 16, 2023 22:11 ()
Why? Ανενεργό feed status. Οι διακομιστές μας δεν ήταν σε θέση να ανακτήσουν ένα έγκυρο podcast feed για μια παρατεταμένη περίοδο.
What now? You might be able to find a more up-to-date version using the search function. This series will no longer be checked for updates. If you believe this to be in error, please check if the publisher's feed link below is valid and contact support to request the feed be restored or if you have any other concerns about this.
Manage episode 346928048 series 2811669
- play_arrow
Lithium Toxicity
Dr Swapnil Pawar
Lithium Toxicity
Written by Dr Andrew Lam
Interpretation of Lithium Levels
Therapeutic level – 0.8 – 1.2mmol/L
Mild Toxicity – 1.5 – 2.5mmol/L
Moderate to Severe Toxicity from – 2.5 – 3.5mmol/L
Severe toxicity – >3.5mmol/L
Symptoms of Toxicity
Gastrointestinal – nausea, vomiting and diarrhea. (More common in acute toxicity)
Neurological – ataxia, sluggishness, slurred speech, agitation and tremors. In more severe toxicity, can result in seizures and encephalopathy (More common in chronic toxicity)
Cardiovascular – dysrhythmias and cardiovascular collapse (rarer)
Management of Lithium Toxicity
In acute ingestions – whole bowel contamination with polyethylene glycol:
If immediate release lithium – must be given within 1 hour of ingestion
If sustained release lithium – must be given within 4 hours of ingestion
Judicious fluid resuscitation to allow for intrinsic renal elimination
If levels >5mmol/L or >4mmol/L with renal failure or signs of severe toxicity, elimination with haemodialysis is required. Usually, 1 session of intermittent haemodialysis is sufficient. Repeat lithium levels must be taken 6 hours post-dialysis, and if <1mmol/L, dialysis can be ceased.
The post Lithium Toxicity first appeared on Critical Care Education.
32 επεισόδια
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