Dr RR Baliga's "Got Knowledge Doc" Podkast podcast

21:04

Step into the mysterious and visually stunning world of The Electric State as host Francesca Amiker takes you behind the scenes with the creative masterminds who brought Simon Stålenhag’s dystopian vision to life. In this premiere episode, directors Joe and Anthony Russo, stars Millie Bobby Brown and Chris Pratt, writers Christopher Markus and Stephen McFeely, and producers Angela Russo-Otstot and Chris Castaldi reveal how they transformed a haunting graphic novel into an epic cinematic experience. Watch The Electric State coming to Netflix on March 14th. Check out more from Netflix Podcasts . State Secrets: Inside the Making of The Electric State is produced by Netflix and Treefort Media.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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“Got Knowledge Doc” Podkast with Dr. RR Baliga The "Got Knowledge Doc" Podkast, hosted by Dr. Ragavendra R. Baliga, is a knowledge-driven platform designed for physicians and healthcare providers seeking to stay at the forefront of medical science and innovation. With a distinguished career in cardiovascular medicine and academic leadership, Dr. Baliga engages with leading experts to explore cutting-edge research, emerging technologies, and transformative insights in medicine and beyond. Each episode delves into topics such as cardiology, precision medicine, artificial intelligence in healthcare, epigenetics, and medical ethics—making complex advancements accessible and relevant to clinical practice. Importantly, this podcast is purely educational and does not provide medical advice or clinical opinions. Join Dr. Baliga and his esteemed guests as they navigate the evolving landscape of medical knowledge, empowering healthcare professionals with evidence-based insights that shape the future of patient care.

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Dr RR Baliga's "Got Knowledge Doc" Podkast

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411 επεισόδια

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🧠 Fast Wins, Flawed Logic, Real Choices 2:20

πριν 5 hours2:20

2:20

🧠 People often say they want big wins (like lotteries), but in practice, they choose what wins more often —even if it pays less. 🎮 In experiments, when outcomes are shown side-by-side, we tend to favor the “frequent winner.” 📉 This bias can make us overlook rare, high rewards—shaping real-world choices in money, health, and risk. 🔍 Bottom line: It’s not just what we choose, but how the choice is shown that changes everything.…

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Dr. RR Baliga’s Philosophical Discourses: Zhuangzi (China, c. 369–286 BCE) – Taoist Philosopher 3:25

πριν 1 day3:25

3:25

Zhuang Zhou, also known as Zhuangzi, was an influential 4th-century BCE Chinese philosopher during the Warring States period. As a foundational figure of Taoism, he authored the Zhuangzi , a text known for its profound philosophical insights, parables, and critiques of societal norms, emphasizing personal freedom and harmony with the Tao. His ideas remain central to Chinese philosophy and continue to inspire discussions on ethics, metaphysics, and human nature.…

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Hands Down, Cream Wins! 🖐️🧴💥 Delgocitinib vs Alitretinoin in Chronic Eczema 3:56

πριν 2 μέρες3:56

3:56

🧴 Delgocitinib cream outperformed oral alitretinoin in treating severe chronic hand eczema over 24 weeks. 📉 Greater reduction in HECSI, 😊 better quality of life, and ⚠️ fewer side effects make it a promising non-steroidal alternative. 💊 Time to rethink systemic pills — topical wins hands down! 🖐️✅…

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🧠🦴🚼 “Brains, Balance, and Birth: Cracking the Pelvic Code 2:53

πριν 3 μέρες2:53

2:53

🧬 Human pelvic evolution reflects a tug-of-war between 🚶‍♀️ efficient walking, 🧠 growing brains, and 🚼 safe childbirth. Using AI and genetic data from 31,115 individuals, Xu et al. found the pelvis is highly heritable, sex-dimorphic, and shaped by multiple selective pressures—not just bipedalism or birth. Larger canals ease delivery but risk 💥 pelvic floor disorders, while narrower ones boost mobility but raise ⚠️ labor complications. This study reframes the “obstetrical dilemma” as a 🔄 multifactorial evolutionary compromise.…

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🫁💥 “Lung Clues & Blood Blues: How Tiny Lung Vesicles Spark Deadly Cancer Clots” 🧬🩸 2:43

πριν 4 μέρες2:43

2:43

🩸 Summary: Lung interstitial macrophages, activated by tumor-derived CXCL13, release integrin β2⁺ extracellular vesicles (sEVs) 🧬 that bind platelet GPIb 🧲, triggering clot formation across the body. These sEVs are both a driver of cancer-associated thrombosis and a potential biomarker for early risk detection 🎯, offering safer, targeted therapeutic opportunities 💉.…

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Inflammation 🔥, Dopamine 💊, and Apathy 😐: A Neuroimmune Pathway in Brain Fog? 3:30

πριν 5 μέρες3:30

3:30

Cancer cachexia isn’t just weight loss—it’s a hijacking of motivation 😔. Elevated IL-6 🔥 activates a brainstem-to-basal ganglia circuit 🧠 that suppresses dopamine 💊 in the nucleus accumbens, leading to effort-based apathy 💤. Blocking IL-6 or boosting dopamine restores drive without changing weight, revealing a treatable neuroimmune pathway 💡.…

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“🧠 Fewer Strokes, 🚫 No Bleeds, ✅ Stronger Choice: Clopidogrel After PCI? 4:17

πριν 6 μέρες4:17

4:17

🧪 SMART-CHOICE 3 in a Nutshell 🟣 Clopidogrel beat 🟠 aspirin post-PCI: 📉 Fewer MACCE (4.4% vs 6.6%) 🩸 Same bleeding risk 🍽️ Fewer GI events ⚠️ Editorial: Fragile stats, late benefit, open questions on lifelong therapy. 🎯 Verdict: Promising—but not bulletproof.

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Mitochondria. Medicine. Miracles 2:31

πριν 7 μέρες2:31

2:31

🔋 Mitochondrial transplants are emerging as a powerful therapy to repair damaged cells, boost energy, and even reverse aging. From saving 🫀 baby hearts to protecting 🧠 stroke-affected brains, this tiny powerhouse may revolutionize medicine—one cell at a time. 🧬💉✨

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Dr. RR Baliga’s Philosophical Discourses: Plato (Greece, 427–347 BCE) – Founder of the Academy 4:48

πριν 8 μέρες4:48

4:48

Plato (c. 428-348 BCE), a foundational figure in Western philosophy, was a student of Socrates and teacher of Aristotle. He established the Academy in Athens and is known for his theory of Forms, dialogues on justice, ethics, and politics, and lasting influence on philosophy, science, and education.

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Mitochondria the Tiny Travelers, Big Impact, Bold Future 1:49

πριν 9 μέρες1:49

1:49

🧬 Mitochondria are on the move! Once thought to stay put, these powerhouses travel between cells 🚀—healing neurons 🧠, boosting immunity 🛡️, and even aiding cancer cells ⚠️. Scientists are now exploring how to harness this dynamic dance for future therapies 💉.

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From Cold to Bold: The Legacy of Winter Conception 3:21

πριν 10 μέρες3:21

3:21

❄️ Conceived in the Cold? Individuals conceived during colder months show higher brown fat activity, increased thermogenesis, and lower BMI as adults. 🔬 Using PET/CT, NIR-TRS, and doubly labeled water (DLW), the study linked preconception cold exposure to greater energy expenditure and reduced visceral fat. 🧬 The key factor: Temperature and its diurnal variation before conception — not birth season — predicts adult brown adipose tissue (BAT) function. 📉 Cold-induced BAT activation leads to better cold adaptation, improved CIT, DIT, and total energy expenditure (TEE) — even years later. 🧠 Researchers propose PfOHaD ( Pre-fertilization Origins of Health and Disease ) — expanding DOHaD to include paternal cold exposure as a metabolic epigenetic switch.…

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“Heart on Fire? Timing Colchicine Right ⏳🧯🏥” 3:15

πριν 11 μέρες3:15

3:15

Colchicine 💊, once a humble gout remedy, is now reshaping coronary care 🫀. Trials show it reduces events in stable CAD ✅, but its benefit post-MI ⛑️ depends on timing ⏰. Inflammation matters — and so does when we strike. Colchicine in CAD: Small Pill, Big Debate 💊🔥🫀 An ancient anti-inflammatory has found new life in cardiology — reducing heart attacks when started late, but disappointing when given early after an MI. Bottom Line: Timing matters. Too soon, and it fizzles. Wait until the fire cools, and colchicine shines. ⏰✨…

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The Kilimanjaro Cure 🌋🥬:: 🧬: How Heritage Diets Heal 3:01

πριν 12 μέρες3:01

3:01

🌿 Switching to a Western diet 🍔 increased inflammation 🔥 and metabolic dysfunction. 🍌 Mbege and traditional foods calmed the immune system 🧘 and boosted IL-10 🕊️.

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“Salted Truths: 🧂❤️⚖️ Rethinking Sodium for Heart and Kidney Health” 2:04

πριν 13 μέρες2:04

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Not all salts are created equal! 🧂 Sodium chloride raises blood pressure and harms the heart 😈, while sodium bicarbonate may protect kidneys and improve outcomes in CKD/HF patients 🛡️🫀. Chloride channels (CLICs) play a hidden but vital role in heart health 🔌❤️. We need large RCTs 🧪📊 to guide smarter, personalized salt strategies for better cardiovascular care 🎯🌍.…

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💊 Oral Semaglutide Enters the Arena — The SOUL Trial 3:11

πριν 14 μέρες3:11

3:11

The SOUL trial 🧪 showed that oral semaglutide 💊 significantly reduced major cardiovascular events ❤️ (MACE) in people with type 2 diabetes 🩸 and ASCVD/CKD 🚑. Over ~4 years, it cut heart attacks 💥, lowered HbA1c 📉, reduced weight ⚖️, and inflammation 🔥 — all with a once-daily pill 🕊️ and no rise in serious side effects.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Dr. RR Baliga’s Philosophical Discourses: Mozi (China, c. 470–391 BCE) – Founder of Mohism 3:48

πριν 15 μέρες3:48

3:48

Mozi, a prominent Chinese philosopher during the Warring States period, founded Mohism, a school of thought emphasizing universal love, meritocracy, anti-war principles, and consequentialist ethics. He advocated for frugality, social welfare, and pragmatic governance guided by Heaven’s will.

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Coronary Artery Disease: Fix the Future, Not Just the Flow 🌍🫀🛠️” 2:14

πριν 16 μέρες2:14

2:14

The Lancet Commission calls for a shift from focusing on late-stage ischaemia to targeting early atherosclerosis (ACAD) 🫀🔍. By detecting and treating plaque early, we can prevent heart attacks, reduce deaths, and promote lifelong heart health 🌍❤️💡.

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🧠💉 “Shots, Shingles, and Sharp Minds: The Brain-Boosting Power of a Vaccine 2:16

πριν 17 μέρες2:16

2:16

💉 A natural experiment in Wales showed that the shingles vaccine (Zostavax) reduced dementia risk by 20% over 7 years. 🧠 The study used a clever birthdate cutoff to mimic randomization and avoid confounding. 👩‍🔬 Women benefited more, suggesting immune or viral mechanisms beyond shingles prevention. 📊 Findings offer hope for low-cost, brain-protective interventions in aging populations.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🚶‍♂️💉 Giant Strides with Weekly Semaglutide Jabs! 3:04

πριν 18 μέρες3:04

3:04

🚶‍♂️ The STRIDE trial tested semaglutide in patients with PAD and type 2 diabetes. 💉 Weekly injections for 52 weeks improved walking distance, pain-free mobility, and quality of life. 📊 Results showed significant gains vs placebo, with low adverse events. 🌟 Semaglutide may offer a new stride forward in treating functional limitations in PAD.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Microbial Enzymes, Human Time: The Xenotopic Way to Live Longer 3:11

πριν 19 μέρες3:11

3:11

🧬 Xenotopic synthetic biology explores using enzymes from microbes (like bacteria and yeast) to reprogram human metabolism and delay aging. 🔋 These “borrowed” enzymes target amino acid levels, mitochondrial function, and redox balance to boost healthspan and fight age-related diseases. 🦠 From methioninase to NDI1 and AOX, these tools may turn microbial chemistry into tomorrow’s longevity medicine.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🏃‍♂️💔 Heartbreak at the Finish Line: Racing Against Cardiac Arrest ⚡🚑 2:55

πριν 20 μέρες2:55

2:55

🏃‍♂️💔 In a study of 29 million race finishers (2010–2023), cardiac arrest rates during marathons and half-marathons stayed steady, but deaths dropped by half. 🧠⚡ Rapid CPR and AED use saved lives, with coronary artery disease—not hypertrophic cardiomyopathy—being the top culprit. 🫀🚑

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🏃‍♂️🧠💡 Move. Spark. Remember: The Brain Boost of Exercise 2:16

πριν 21 μέρες2:16

2:16

🧠 Exercise is a powerful neuroprotective tool—it boosts memory, preserves brain volume, and reduces dementia risk. 💪 Through exerkines like BDNF and irisin, it sparks neurogenesis, clears inflammation, and enhances brain plasticity. 🌱 It also nurtures your gut microbiome and rewires your genes, making movement medicine for the mind.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Dr. RR Baliga’s Philosophical Discourses: Socrates (Greece, 469–399 BCE) – Classical Philosopher 2:51

πριν 22 μέρες2:51

2:51

A brief overview of Socrates, the classical Greek philosopher widely regarded as the founder of Western philosophy. Known for his Socratic method of questioning, he profoundly influenced ethical thought, epistemology, and later philosophical traditions.

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🎙️ “🥗 Plants, 🍽️ Plates, and 🤔 Paradoxes: Decoding Diets for a Long Life” 5:26

πριν 23 μέρες5:26

5:26

🍎 In this episode, we unpack a 30-year study on how diet influences aging. 🥗 AHEI, DASH, and Mediterranean diets boost your odds of healthy aging—by as much as 86%! ⚠️ But not all plant-based diets are equal: hPDI underwhelms, likely due to excluding protective animal foods like fish and dairy. 🚫 Ultra-processed foods, sugary drinks, and trans fats? Aging’s worst enemies. 🎯 Bottom line: Eat smart, age strong.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Hearts on the Line: Choosing Wisely, Saving Lives ❤️🫀 5:19

πριν 24 μέρες5:19

5:19

🫀 Heart transplantation is a life-saving treatment for end-stage heart failure, but donor hearts are scarce. 🔍 Donor selection is complex, involving factors like age, heart size, LV function, and comorbidities. 🌍 The U.S. is more conservative than Europe, with higher donor heart nonuse rates. ⚙️ New tools like Predicted Heart Mass (PHM), Organ Care Systems, and AI models improve matching and outcomes. 💉 Donation after Circulatory Death (DCD) is expanding the donor pool. ⚖️ Ethical concerns and upcoming policy shifts aim for more equitable, data-driven heart allocation.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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⚡ Cardiogenic Shock Strategy: 👁️ Spot It • ✋ Stop It • 💓 Save Lives 5:58

πριν 25 μέρες5:58

5:58

🚑 A rapid-fire guide to cardiogenic shock — from first suspicion to life-saving interventions. 🩺 ACC’s latest on Cardiogenic Shock: 👁️ Early detection with SUSPECT CS 💉 First-line meds: norepinephrine & dobutamine 🛠️ tMCS for refractory cases (Impella, VA-ECMO) 🏥 Transfer to Level 1 centers 🤝 Team-based care = better outcomes 💡 Act fast, save lives!…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Leg Cramps at Night 💤, Relief in Sight 🛌, Powered by Vitamin K2 💊 3:18

πριν 26 μέρες3:18

3:18

🧪 A randomized clinical trial in older adults (65+) found that Vitamin K2 (menaquinone-7, 180 μg/day) significantly reduced nocturnal leg cramps in terms of frequency, severity, and duration—with no adverse effects reported. 🌙🦵💊 This safe (?), over-the-counter supplement may offer a simple, science-backed solution for painful nighttime cramps—avoid it if you’re on warfarin. 🚫💉✅…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🪑 Sit Less. 🏃‍♂️ Move More. ❤️ Live Longer 5:15

πριν 27 μέρες5:15

5:15

📊 Too much sitting hurts the heart. 🧍‍♂️ Ajufo et al. (2024) tracked 89,530 people using accelerometers and found that 🪑 >10.6 hours/day of sitting sharply increases the risk of ❤️ heart failure, 💔 heart attacks, 💓 AFib, and ⚰️ cardiovascular death. 🏃 Even active people aren’t fully protected. 🔁 Replacing just 30 minutes of sitting with movement—🕺 light or 🏋️‍♂️ vigorous—reduces risk. 🧠 The takeaway? Sit less, move more, live longer.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Young, Fit… Gone? The Hidden Dangers of Cardiac Arrest 6:08

πριν 28 μέρες6:08

6:08

🧑‍⚕️💔 Young, Fit… Gone? Every year, thousands of seemingly healthy young adults suffer sudden cardiac arrest (SCA) outside the hospital. 📉 Only 9–16% survive to discharge — yet 90% of survivors leave with good brain function. 🔍 Many have hidden risk factors — hypertension, diabetes, even genetic arrhythmia syndromes like Brugada or Long QT. ⚡ Rapid CPR, AED use, and targeted evaluation (ECG, imaging, genetics) save lives and prevent recurrence. 🧬 Survivors—and their families—may carry silent genetic signals. 🔁 The takeaway? SCA isn’t random. It’s a warning shot. One we can catch—if we’re ready.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Dr. RR Baliga’s Philosophical Discourses: Gautama Buddha (India, c. 563–483 BCE) – Founder of Buddhism 3:13

πριν 29 μέρες3:13

3:13

Siddhartha Gautama, known as the Buddha (“the awakened one”), was a spiritual teacher who founded Buddhism in the 5th or 6th century BCE in South Asia. His core teachings include the Middle Way, the Four Noble Truths, and the Noble Eightfold Path, emphasizing mindfulness, ethics, and liberation from suffering.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🔥 Sizzle, 🔄 Swap, 💪 Survive: Oils That Heal, Fats That Harm 3:22

πριν 4 weeks3:22

3:22

•Olive. Canola. Soybean. •Not just flavor—they’re lifelines. 🌱 •Every 10g a day drops mortality by 16%. •They don’t just cook food—they cook up longevity? 🔥⏳

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Genes, Gender, and Growing Old 3:12

πριν 4 weeks3:12

3:12

🧬 Your mother’s X chromosome may shape how your brain ages. In female mice, when only the maternal X chromosome (Xm) is active, older animals show worse memory 🧠🕳️ than those with random X-inactivation. This is due to imprinted genes — some only expressed from the paternal X (Xp) — which are silent when Xm dominates. 🧠💡 Using CRISPR–Cas9, researchers reactivated 3 Xm-silent genes ( Sash3, Tlr7, Cysltr1 ) and saw improved memory and mitochondrial function ⚡🔋. 👩‍🔬 This highlights inter-female variation in aging and memory — and suggests that epigenetic inheritance from mothers may shape how well we remember… or forget. 🧓🧠❓…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Genes, Families, and Households: Rethinking Biobank Science 6:04

πριν 5 weeks6:04

6:04

🔬 Confounding, Clarity, and Causality Family-based biobanks 🧬 are the next frontier in genetic research—tackling bias 🧠, boosting causal inference 🎯, and revealing insights hidden in the noise of population studies 🌍. It’s not just about big data—it’s about better data 👨‍👩‍👧‍👦.

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🧠 Brain aging decoded! Scientists identify 64 genes & 13 blood proteins linked to aging. 3:11

πριν 5 weeks3:11

3:11

🧠 Brain Aging & Research Advances 🔍 Key Findings: • Brain Age Gap (BAG): Difference between estimated and chronological brain age. • 64 genes identified as influencing brain aging. • 13 proteins in blood linked to accelerated/slowed brain aging. 🩺 Potential Interventions: • 13 anti-aging drugs (e.g., Rapamycin, Dasatinib) show promise in slowing decline. • Plasma proteomics reveals key biomarkers for early intervention. 🌍 Influencing Factors: • Socioeconomic status, pollution, and gender inequality impact brain aging. • Functional connectivity decline linked to cognitive disorders. 🚀 Future Directions: • Clinical trials needed for drug validation. • Genetic & proteomic studies should expand to diverse populations.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Brain Slime to the Rescue! 🧠🛡️ How Mucins Protect Against Aging & Cognitive Decline 🚀 4:58

πριν 5 weeks4:58

4:58

The blood-brain barrier (BBB) 🛡️ protects the brain from harmful molecules but weakens with aging 🧓, leading to neuroinflammation 🔥 and cognitive decline 📉. Mucins 🧬, slippery proteins in the glycocalyx 🏗️, help maintain BBB integrity 🧠. This study found that mucin loss 🚨 increases BBB permeability, allowing toxins to enter. Using gene therapy 🧪, researchers restored mucins, improving memory and learning 📈 in aged mice. This breakthrough suggests that mucin-based treatments 🏥 could prevent neurodegenerative diseases like Alzheimer’s and Parkinson’s 🎯 while also enhancing brain drug delivery 🚀.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🌍 One Billion Suffer: Decoding Migraine 🧠💊🚀 3:58

πριν 5 weeks3:58

3:58

🧠 Migraine is a complex neurological disorder affecting 1 billion people worldwide. Historically misunderstood, it was once seen as a vascular or psychological issue but is now recognized as a brain network dysfunction involving the hypothalamus and limbic system. 💊 Gepants and CGRP blockers have revolutionized treatment, though they only work for some patients. Triggers like stress, hormones, diet, and environmental factors play a role, and genetics influences susceptibility. 🤖 AI-driven research is helping predict attacks and personalize treatments, while new studies are shifting focus beyond headaches to cognitive and systemic symptoms. Future research aims to uncover additional pathways and improve long-term management. 🚀…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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“Alcohol: A Double-Edged Sword ⚖️🍷 – Cancer, Heart Risks & What You Need to Know!” 3:38

πριν 5 weeks3:38

3:38

Alcohol is a proven carcinogen 🚨, increasing the risk of at least 7 cancers (mouth, throat, breast, liver, etc.) 🦠💀. Even small amounts (5g ethanol/day) raise cancer risk, with no safe threshold 📊🚫. Similarly, exceeding 14 drinks/week (men) or 7 (women) raises CHD risk by up to 43% 💔📈. Past claims of heart benefits from moderate drinking are now being challenged 🧐❓. Best advice? Limit or avoid alcohol for better long-term health 🚫🥃✔️.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Dr. RR Baliga’s Philosophical Discourses: Heraclitus (Greece, c. 535–475 BCE) – Pre-Socratic Philosopher 3:29

πριν 5 weeks3:29

3:29

Heraclitus (c. 500 BC), a pre-Socratic philosopher from Ephesus, is renowned for his doctrine of perpetual change and the unity of opposites, encapsulated in the phrase “Everything flows” and “No man ever steps in the same river twice.” His concept of logos as the rational order of the universe influenced ancient and modern philosophy, including thinkers like Plato, Aristotle, and Hegel. Known as “the dark” philosopher for his cryptic style and paradoxical ideas, Heraclitus viewed strife as fundamental to justice and saw fire as the primal element of existence. His legacy endures in the study of cosmology, metaphysics, and dialectics.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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☕ Brewed for Your Gut? 🔬 Coffee, Microbiome, & Metabolic Magic! 🦠✨ 2:34

πριν 5 weeks2:34

2:34

☕ Coffee & Gut Microbiome 🦠 🔬 A multi-cohort study (N = 22,867) found a strong link between coffee consumption and the gut bacterium Lawsonibacter asaccharolyticus. 🧪 Metabolomics identified key coffee-derived metabolites like quinic acid, hippurate, and trigonelline. 📊 Machine learning (AUC = 0.89) confirmed microbiome composition predicts coffee intake. 🧫 In vitro studies showed coffee stimulates L. asaccharolyticus growth. ⚙️ Findings suggest polyphenols in coffee shape gut microbiota and metabolic pathways. 🚀 Future research aims to explore dose-dependent effects, health benefits, and microbiome-driven nutrition.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Move over, Bionic Man—this titanium heart 🫀⚙️ just made science fiction a reality! 🚀💙 2:22

πριν 5 weeks2:22

2:22

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🔬 Antioxidants & Health: The Science Behind the Hype ❌❤️ 2:39

πριν 6 weeks2:39

2:39

🔬 Antioxidants & Health: Myths vs. Reality ❌🍊💊 Despite popular belief, vitamins C & E do not reduce the risk of cancer, heart disease, or chronic illness 🚫❤️. High doses of vitamin A increase the risk of hip fractures & prostate cancer ⚠️🦴, while vitamin E is linked to respiratory infections, prostate cancer, and even death 😷❌. However, a specific combination of antioxidants (C, E, zinc, copper, lutein, zeaxanthin) slows vision loss in age-related macular degeneration (AMD) 👁️🧡. A multiomic study identified GSTO1 as the best biomarker for zinc deficiency 🧪🔍, but further validation is needed. Takeaway? Antioxidants have specific benefits, but not as universal disease preventers! ⚖️🚀…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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“🩸 Iron & Folate: The Power of Nutrients for a Healthy Life 💪🍎” 3:34

πριν 6 weeks3:34

3:34

🔬 Anemia & Folate: Key Insights 🩸 Anemia is primarily caused by iron deficiency in the U.S., especially in pregnancy (30% prevalence). 📊 NHANES data shows high iron deficiency in young females (up to 77.5% at ferritin 45 mg/day may cause nausea & constipation. 👶 Maternal iron status affects infant birth weight, and delayed cord clamping improves newborn iron stores. 🌍 In low-income countries, anemia is also linked to malaria, parasites, and hemoglobinopathies. 🍞 Folic acid fortification since 1998 has reduced neural-tube defects, making folate deficiency rare in the U.S.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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Vitamin B12: The Brain & Blood Booster? 🩸🧠💪 2:54

πριν 6 weeks2:54

2:54

Vitamin B12: Essential for Health 🩸🧠 Vitamin B12 is crucial for red blood cell formation, brain function, and DNA synthesis. Found in animal-based foods 🥛🍳🐟, those on vegan diets need fortified foods or supplements 💊. Deficiency can cause anemia, neurological issues, and cognitive decline ⚠️. High-risk groups include vegans, vegetarians, older adults, and individuals with malabsorption conditions 🏥. Maternal deficiency affects fetal development 🤰👶. Absorption declines with age, and severe cases (e.g., pernicious anemia) may require high-dose supplements or injections 🚑. Research on its role in preventing cognitive decline remains inconclusive 🤔.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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🔥 Vitamin D & Multiple Sclerosis: Defending the Nervous System 🧠🛡️ 3:03

πριν 6 weeks3:03

3:03

🧠 High-dose Vitamin D (100,000 IU biweekly) reduced disease activity in Clinically Isolated Syndrome (CIS) of MS 🌞📉. Patients had fewer MRI lesions 🖥️, longer time to disease activity ⏳, but no significant impact on relapses ❌. Well-tolerated with minimal side effects ⚕️, These findings support further research on Vitamin D as an MS therapy 🔬🚀.…

Dr RR Baliga's "Got Knowledge Doc" Podkast

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☀️ Vitamin D: The Sunshine Nutrient for Strong Bones & Immunity? 🦴🛡️” 5:59

πριν 6 weeks5:59