Ep. 23: "Ep 23 Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy"—with Raphael Sirtoli and Dave Feldman

Tucker Goodrich: Debugging Life

Introduction So apparently there is some demand for discussion/debate on the topic of seed oils and health. Dave Feldman (Ep. 9) had considered doing this at his recent conference, but couldn’t fit in the time. He’s since regained interest in the idea, and reached out to Andreas Eenfeldt and Ted Naiman, who have expressed skepticism. They replied: “We decline as we feel this debate is a distraction. The reason is that we see no good scientific evidence for replacing any source of added pure fat with another. It's not the right question.” Since there’s so much interest, and clearly that opinion is not defensible—probably why they avoided the debate!—Raphael Sirtoli volunteered to take the con side of a debate, topic: “Doctors Should Tell Patients that High Linoleic Acid Seed Oils are Unhealthy” This was a debate proposition that Raphi had suggested recently, and it had also been declined. (More about that in a future episode.) So, here we are. Please enjoy, and as always, post questions or comments in the comments below. The debate on Dave’s YouTube channel is here: https://www.youtube.com/live/JDsbpAJ28U4?si=4n7mSt56JiQDXTGN _______________________________________

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Tucker Goodrich Substack: https://tuckergoodrich.substack.com/ Twitter: https://twitter.com/TuckerGoodrich Youtube: https://www.youtube.com/tuckergoodrich0 Apple podcast: https://podcasts.apple.com/us/podcast/tucker-goodrich-podcast/id1617481825 Spotify podcast: https://open.spotify.com/show/7wVZ3TnRjGsa1cP2gzWY0y Podcast: https://sites.libsyn.com/408758 Blog (deprecated, but still a lot there!): http://yelling-stop.blogspot.com/ _______________________________________ Show Notes Pro Ramsden, C. E., Zamora, D., Majchrzak-Hong, S., Faurot, K. R., Broste, S. K., Frantz, R. P., Davis, J. M., Ringel, A., Suchindran, C. M., & Hibbeln, J. R. (2016). Re-Evaluation of the Traditional Diet-Heart Hypothesis: Analysis of Recovered Data from Minnesota Coronary Experiment (1968-73). BMJ, 353. https://doi.org/10.1136/bmj.i1246

Steinberg, D., Parthasarathy, S., Carew, T. E., Khoo, J. C., & Witztum, J. L. (1989). Beyond Cholesterol. Modifications of Low-Density Lipoprotein That Increase Its Atherogenicity. The New England Journal of Medicine, 320(14), 915–924. https://doi.org/10.1056/NEJM198904063201407

de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J. L., Monjaud, I., Guidollet, J., Touboul, P., & Delaye, J. (1994). Mediterranean Alpha-Linolenic Acid-Rich Diet in Secondary Prevention of Coronary Heart Disease. Lancet (London, England), 343(8911), 1454–1459. https://doi.org/10.1016/s0140-6736(94)92580-1

Wien, M., Rajaram, S., Oda, K., & Sabaté, J. (2010). Decreasing the Linoleic Acid to α-Linolenic Acid Diet Ratio Increases Eicosapentaenoic Acid in Erythrocytes in Adults. Lipids, 45(8), 683–692. https://doi.org/10.1007/s11745-010-3430-3

Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., Nordestgaard, B. G., Watts, G. F., Bruckert, E., Fazio, S., Ference, B. A., Graham, I., Horton, J. D., Landmesser, U., Laufs, U., … Ginsberg, H. N. (2020). Low-Density Lipoproteins Cause Atherosclerotic Cardiovascular Disease: Pathophysiological, Genetic, and Therapeutic Insights: A Consensus Statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 41(24), 2313–2330. https://doi.org/10.1093/eurheartj/ehz962

Con Arris, F. A., Thai, V. T. S., Manan, W. N., & Sajab, M. S. (2020). A Revisit to the Formation and Mitigation of 3-Chloropropane-1,2-Diol in Palm Oil Production. Foods, 9(12), 1769. https://doi.org/10.3390/foods9121769

de Lorgeril, M., Renaud, S., Mamelle, N., Salen, P., Martin, J. L., Monjaud, I., Guidollet, J., Touboul, P., & Delaye, J. (1994). Mediterranean Alpha-Linolenic Acid-Rich Diet in Secondary Prevention of Coronary Heart Disease. Lancet (London, England), 343(8911), 1454–1459. https://doi.org/10.1016/s0140-6736(94)92580-1

Ramsden, C. E., Faurot, K. R., Zamora, D., Palsson, O. S., MacIntosh, B. A., Gaylord, S., Taha, A. Y., Rapoport, S. I., Hibbeln, J. R., Davis, J. M., & Mann, J. D. (2015). Targeted alterations in dietary n-3 and n-6 fatty acids improve life functioning and reduce psychological distress among patients with chronic headache: A secondary analysis of a randomized trial. Pain, 156(4), 587–596. https://doi.org/10.1097/01.j.pain.0000460348.84965.47

Ramsden, C. E., Zamora, D., Faurot, K. R., MacIntosh, B., Horowitz, M., Keyes, G. S., Yuan, Z.-X., Miller, V., Lynch, C., Honvoh, G., Park, J., Levy, R., Domenichiello, A. F., Johnston, A., Majchrzak-Hong, S., Hibbeln, J. R., Barrow, D. A., Loewke, J., Davis, J. M., … Mann, J. D. (2021). Dietary Alteration of N-3 and N-6 Fatty Acids for Headache Reduction in Adults with Migraine: Randomized Controlled Trial. BMJ, 374, n1448. https://doi.org/10.1136/bmj.n1448

Rastogi, T., Reddy, K. S., Vaz, M., Spiegelman, D., Prabhakaran, D., Willett, W. C., Stampfer, M. J., & Ascherio, A. (2004). Diet and risk of ischemic heart disease in India. The American Journal of Clinical Nutrition, 79(4), 582–592. https://doi.org/10.1093/ajcn/79.4.582

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