Alexander Disease Research Update - Episode #17: 1) New IPS Cell Line, 2) Acetylation And GFAP, And 3) STAT3 As A Key Regulator Driving GFAP Accumulation Alexander Disease Research Update podcast

Alexander Disease Research Update « »

Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation

1y ago 24:11

Μοίρασέ το

Το περιεχόμενο παρέχεται από το Albee Messing. Όλο το περιεχόμενο podcast, συμπεριλαμβανομένων των επεισοδίων, των γραφικών και των περιγραφών podcast, μεταφορτώνεται και παρέχεται απευθείας από τον Albee Messing ή τον συνεργάτη της πλατφόρμας podcast. Εάν πιστεύετε ότι κάποιος χρησιμοποιεί το έργο σας που προστατεύεται από πνευματικά δικαιώματα χωρίς την άδειά σας, μπορείτε να ακολουθήσετε τη διαδικασία που περιγράφεται εδώ https://el.player.fm/legal.

Albee Messing, Rachel Battaglia, and Tracy Hagemann discuss the following recent publications:

[01:45] A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells

Stem Cell Reports 18, 1701-1720 (2023)

[includes new iPS cell line from an individual with Alexander disease] [full text]
[05:39] Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications

Journal of Visualized Experiments 18, 55655 (2017)

[includes data on acetylation of lysines in GFAP] [full text]
[10:26] STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease

Cells 12, 978 (2023)

[identification of one of the key mechanisms responsible for the increase in GFAP levels in Alexander disease] [full text]
[22:35] Questions from email: does Alexander disease affect menstrual cycles?
Send your questions and feedback to: axdrupodcast@waisman.wisc.edu

Help support research on Alexander Disease at the University of Wisconsin-Madison's Waisman Center:

https://alexander-disease.waisman.wisc.edu/donate/

Κεφάλαια

1. Alexander Disease Research Update - Episode #17: 1) new iPS cell line, 2) acetylation and GFAP, and 3) STAT3 as a key regulator driving GFAP accumulation (00:00:00)

2. A defined roadmap of radial glia and astrocyte differentiation from human pluripotent stem cells (00:01:46)

3. Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications (00:05:39)

4. STAT3 Drives GFAP Accumulation and Astrocyte Pathology in a Mouse Model of Alexander Disease (00:10:26)

5. Questions (00:22:35)

23 επεισόδια