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Το περιεχόμενο παρέχεται από το Bloody Minded Crew. Όλο το περιεχόμενο podcast, συμπεριλαμβανομένων των επεισοδίων, των γραφικών και των περιγραφών podcast, μεταφορτώνεται και παρέχεται απευθείας από τον Bloody Minded Crew ή τον συνεργάτη της πλατφόρμας podcast. Εάν πιστεύετε ότι κάποιος χρησιμοποιεί το έργο σας που προστατεύεται από πνευματικά δικαιώματα χωρίς την άδειά σας, μπορείτε να ακολουθήσετε τη διαδικασία που περιγράφεται εδώ https://el.player.fm/legal.

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<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/exile-3411195">Exile</a></span>

<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/exile-3411195">Exile</a></span> podcast artwork

<div class="span index">1</div> <span><a class="" data-remote="true" data-type="html" href="/series/exile-3411195">Exile</a></span> podcast artwork

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Exile

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Welcome to Exile, a podcast about Jewish lives under the shadow of fascism. Narrated by award-winning screen and stage actor, Mandy Patinkin. Untold stories and firsthand accounts drawn from intimate letters, diaries and interviews found in the Leo Baeck Institute’s vast archive. Each episode, a story of beauty and danger that brings history to life. Because the past is always present. Starting November 1, episodes are released weekly every Tuesday. The Leo Baeck Institute, New York | Berlin is a research library and archive focused on the history of German-speaking Jews. Antica Productions produces award-winning non-fiction podcasts, films and series which inform and inspire audiences around the world.

Bloody Minded

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Το περιεχόμενο παρέχεται από το Bloody Minded Crew. Όλο το περιεχόμενο podcast, συμπεριλαμβανομένων των επεισοδίων, των γραφικών και των περιγραφών podcast, μεταφορτώνεται και παρέχεται απευθείας από τον Bloody Minded Crew ή τον συνεργάτη της πλατφόρμας podcast. Εάν πιστεύετε ότι κάποιος χρησιμοποιεί το έργο σας που προστατεύεται από πνευματικά δικαιώματα χωρίς την άδειά σας, μπορείτε να ακολουθήσετε τη διαδικασία που περιγράφεται εδώ https://el.player.fm/legal.

Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.
Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au

… continue reading

36 επεισόδια

#Science #Fitness #Biology #Podcasting Education #Medicine #Bloody Minded Crew #Haematology #Hematology #FOAM #Meded #Med School #Blood #Coagulation #Lymphoma

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Bloody Minded

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Αρχική οθόνη σειράς•Feed

Το περιεχόμενο παρέχεται από το Bloody Minded Crew. Όλο το περιεχόμενο podcast, συμπεριλαμβανομένων των επεισοδίων, των γραφικών και των περιγραφών podcast, μεταφορτώνεται και παρέχεται απευθείας από τον Bloody Minded Crew ή τον συνεργάτη της πλατφόρμας podcast. Εάν πιστεύετε ότι κάποιος χρησιμοποιεί το έργο σας που προστατεύεται από πνευματικά δικαιώματα χωρίς την άδειά σας, μπορείτε να ακολουθήσετε τη διαδικασία που περιγράφεται εδώ https://el.player.fm/legal.

Baffled by blood? Confused by coags? Traumatised by TTP? Planning on quitting medical school because you've just finished haem block? Join the registrars of the Bloody Minded Crew as they tour the world of haematology one topic at at a time while procrastinating from their day jobs.
Your time is precious, so to maximise your return we look at each topic at a variety of levels so you can tailor your learning. Check out more at www.bloodyminded.com.au

… continue reading

36 επεισόδια

#Science #Fitness #Biology #Podcasting Education #Medicine #Bloody Minded Crew #Haematology #Hematology #FOAM #Meded #Med School #Blood #Coagulation #Lymphoma

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1
Episode 35 - The Other Resus | Introduction to Blood Groups 49:57

πριν 4 μέρες49:57

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49:57

We’ve been out of line with the rest of #FOAM #MedEd podcasts for the longest time. Forget that haematology stuff, it’s time to talk about RESUS. Break out your adrenaline, it’s time to crack some chests and… wait what? You meant Rhesus ? With an H? Oh right… okay. Put down those trauma shears as the only thing we’ll be cracking open are the ISBT Red Cell Immunogenetics guidelines. Join the Bloody Minded Crew take you though the basics of blood grouping with a focus on ABO and Rhesus. Timestamps: 0:56 - Cale needs help with the target 3:00 - Intro to blood groups 6:02 - What is a "blood group?" 8:40 - Historical diversion on blood groups! 9:47 - Cale speaks flawless German 13:49 - The ABO group: the hatted and the hatless 18:12 - The Bombay phenotype! No hat, no hair. 20:38 - ABO frequencies 21:11 - ABO compatibilities 21:49 - Interesting (to us) ABO tidbits 24:43 - Intro to Rhesus 29:13 - Nomenclature - RhD, C, c, E, e 36:27 - Wiener classification (brace yourself) 46:27 - Take home messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 34 - On the Wards: I would do anything for blood – but I won’t do that | Transfusion Reactions 1:02:08

πριν 25 μέρες1:02:08

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1:02:08

Do you fear – The Power of Blood? Have you been warned – You can’t Hurry Blood? Today we tackle all the ways Blood (and love) can go wrong. . . and how to manage it on the wards. Too cryptic? Join Bloody Minded's own consultant haematologist Dr Alison Chandler and the rest of the Bloody Minded Crew as we cover the many and varied reactions patients can have when you try and fix that haemoglobin level on the ward. Timestamps 00:53 - 3-4 nerds chatting about nonsense 03:37 - Your first transfusion reaction 05:08 - What is a transfusion reaction? 5:52 - Categorising transfusion reactions 7:26 - Acute febrile reactions 17:20 - Summary of acute febrile reactions 17:45 - Acute non-febrile transfusion reactions 22:11 - Workup and management of an acute reaction 37:44 - Delayed febrile reactions 50:08 - Delayed non-febrile reactions 53:46 - Summaries Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 33 - CAR-T and Chromothripsis | Multiple Myeloma Review with Dr Christian Bryant 1:02:02

πριν 6 weeks1:02:02

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1:02:02

Myeloma beware, it's time to bring out the big guns. We are incredibly thankful to be joined by a peak predator of plasma cells, Dr. Christian Bryant. He is a consultant Haematologist at RPA in Sydney, has a PhD on the immunology of myeloma and is driven by a passion to improve the treatment and understanding of all things myeloma. TIMESTAMPS 2:18 - Intro to Christian Bryant 3:05 - Why Haematology? 5:31 - Why (oh god why) myeloma? 7:28 - Heavy metal, heavy chains 9:28 - Chromothripsis - The Cause That Breaks The Camel's Back? 13:45 - In praise of plasma cells 18:38 - Genomics to risk-stratify precursor states - should we bother? 20:32 - Predicting response and high risk disease 21:43 - IMS Criteria - High Genomic Risk 28:22 - Response Kinetics - When are you nervous? 31:31 - Balancing maintenance Len vs. secondary malignancies 39:34 - Other agents for maintenance? 44:44 - CAR-T - A New Hope? 49:10 - T cell exhaustion 50:21 - What are the CAR-T target molecules for MM? 53:27 - Any hope for a cure? 57:35 - MRD Matters Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 32 - Phagocytose. Pray. Love. | Haemophagocytic Lymphohistiocytosis (HLH) 41:19

πριν 7 weeks41:19

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41:19

Ferritin keeps climbing and you’re getting jumpy? Did you consult Haem and then they were bedside 5 minutes later? Ever had to donate your own blood to test the patient for something? Join Nick, Cale and Bashar as we unpack a very special bonus episode on another deadly TLA, HLH. TIMESTAMPS 3:24 - History of HLH 5:26 - What is a histiocyte? 7:44 - How do you turn *off* an immune response? 8:52 - HLH - A Definition 10:49 - What are NK cells? 13:03 - Primary HLH - "HLH Disease" 13:34 - Secondary HLH - "HLH Syndrome" 14:46 - Causes of familial HLH 16:34 - Infective causes 18:05 - Malignant causes 20:24 - Clinical presentation and diagnostic criteria 32:47 - H-Score 34:36 - Treatment - Replacing Your Dodgy Off Switch 38:04 - Prognosis 38:55 - Take Home Messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 31 - Advanced Myeloma Nursing with A/Prof Tracy King 54:25

πριν 8 weeks54:25

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54:25

Thankfully, it's time for an actual expert to join us again on Bloody Minded! We are thrilled to be sitting down and chatting with A/Prof. Tracy King , Myeloma CNC from RPA Hospital in Sydney, Co-Founder and past president of the HSANZ Nursing Group. From convenient treatment schedulers to the side effects we should be thinking more about to many ideas to improve clinical practice, this is a veritable hour of power worth diving into. TIMESTAMPS 2:23 - Intro to Tracy King 3:30 - A Nightingale Sang in Hammersmith Square 5:22 - How did you get into myeloma nursing? 9:35 - If not nursing, what? 10:50 - What is a CNC? 14:12 - Nursing expertise in myeloma - best supportive care 16:57 - The most asked questions 19:54 - Strategies to manage complex regimens 23:13 - MyeTxScheduler - A Godsend 26:37 - What do we miss, what should we be asking more? 28:21 - The crux of communication issues 29:33 - "What matters to you today" 29:49 - Patient advocacy groups 32:04 - Steroid side effects - there's just so much dex... 35:37 - M protein variations - how to see the forest for the trees 38:22 - Time toxicity 45:44 - Quality of life assessment tools 49:35 - How to get started in advocacy/education/further work? 51:57 - Organisations - find your tribe Also we promised to link MyeTx here so have at it https://rego.interact.technology/myetx/#/main Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 30 - Schnitzler’s List | Other Paraprotein Associated Diagnoses 36:18

πριν 9 weeks36:18

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36:18

All that glitters isn’t gold, and all that paraproteins isn’t myeloma. But if we’re not going to blame myeloma, then what else might be responsible? Hold on to your M-Spikes as we the Bloody Minded Team dive into the weird and wonderful world of paraproteins causing havoc in patients without myeloma. This episode isn’t for the faint of blood so get ready for an advanced look at paraproteins and take a bit of the U out of MGUS. 2:12 - The Problem with "Unknown" Significance 8:45 - Waldenström's macroglobulinemia/Lymphoplasmacytic Lymphoma 11:17 - Marginal zone lymphoma 12:42 - Cold Agglutinin Disease 15:09 - Heavy chain disease 16:27 - POEMS Syndrome 23:10 - Other Paraproteinemic Neuropathies 25:55 - TEMPI 27:03 - CANOMAD 29:16 - Schnitzler Syndrome 31:34 - Scleromyxedema 34:06 - The “paraprotein AND...” approach Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 29 - On The Wards: It's Getting Hot in Here | Febrile Neutropenia 54:13

πριν 10 weeks54:13

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54:13

Its time to hit the hot girl summer of haematology (we're in Australia after all) but also the hot boy winter and Autumn and Spring. Because our patients are hot all year round and sadly all night shift and possibly all throughout your ward round. Welcome to our next On The Wards episode looking at fevers in the haematology patient with a focus on the management of febrile neutropenia. There's a lot to cover in this jumbo sized episode and we're super happy that Dr Alison Chandler agreed to return after last time. Timestamps 2:08 - Episode Overview 4:47 - What is Febrile Neutropenia? 8:59 - Reminder: What are neutrophils 13:08 - Where did the neutrophils go? 18:24 - Why is FN a big deal? 20:00 - Assessing the neutropenic patient 30:15 - Antibiotics: Get them in 33:29 - Bugs: What grows? 36:15 - That fever isn't going away 41:01 - After the fever 42:24 - Can we make the neutrophils go up? 48:00 - Prophylaxis 52:50 - Summary Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 28 - In the Lab: Flow Cytometry, Mass Spectrometry & Cytogenetics in MM 42:26

πριν 11 weeks42:26

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42:26

Can’t get enough of obscure haematological lab chat, can you? Well we’ve got good news for you! Join us today as we delve even deeper into the arcane depths of flow cytometry, mass spectrometry and cytogenetics as they apply to myeloma. We promise we didn’t just make these words up. 02:23 - Flow cytometry: overview 04:01 - The flow cytometer: practical aspects 09:01 - How we interpret flow 11:44 - Myeloma flow markers 14:32 - Quality in flow 21:26 - Mass spectrometry 25:59 - Cytogenetics 27:46 - Cytogenetics assay principles 30:30 - Karyotype abnormalities 31:44 - FISH and SNP arrays 33:05 - Cytogenetics and prognostication in MM 39:59 - Take home points Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 27 - In The Lab: Electrophoresis, Immunoelectrophoresis and Serum Free Light Chain Assays 48:14

πριν 12 weeks48:14

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48:14

Thought you were free of myeloma acronyms? Don’t be ridiculous - this is the haematology lab! We were born in the acronyms, moulded by them. We didn’t see a complete word until advanced training and even then it was nothing but BLINDING. Your lab tests betray you because they belong to us… but in this episode we’ll let you in on some secrets. Join Nick, Cale and Bashar in the haematology (and closely adjacent immunology) lab as they chat about just how we do that electrophoresis, why an iEPG is different to an EPG and just how useful Bence-Jones proteins are(n’t). Timestamps 3:15 - Bone marrows - not as bad as they sound? 4:25 - What even do we do with the marrow? 10:57 - Eponymous plasma cells with weird morphology 13:04 - EPG - Electrophoresis 22:23 - IEPG - Immunoelectrophoresis 29:09 - What's the deal with Bence Jones proteins 33:27 - SFLC Measurements 37:07 - The Hook/Prozone Effect 40:55 - Light chain measurement in renal dysfunction 44:32 - Take Home Messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 26 - Trip to the Congo | Amyloidosis Overview 35:14

πριν 13 weeks35:14

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35:14

MGUS and Myeloma too simple for your tastes? Do you like vague presentations and biopsying many tissues in a sometimes wild goose chase? Why does Congo have all the birefringent apples? Go ' AA aah ' as we TTR y to unpack AL l the problems that come with that most protean of disease - Systemic Amyloidosis! Timestamps 3:04 - Pathophysiology of Amyloid 6:52 - All The Subtypes of Amyloid 7:56 - AA Amyloid 10:08 - ABeta2M Amyloid 11:04 - Age-Related Amyloidosis = wtATTR = WTTA = SSA 14:38 - AL Amyloidosis 16:24 - Diagnosis of Amyloid 22:25 - Clinical Presentation of Amyloid 27:10 - Prognosis 32:17 - Take Home Messages Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 25 - Alphabet Soup | Overview of Myeloma Treatments 47:20

πριν 14 weeks47:20

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47:20

RVd, KTd, CyBorD, DVd, EloRd - Looks like the cat got on the keyboard. Oh wait, this is just the myeloma regimens in day therapy today. Come on a journey as we attempt (mostly successfully) to avoid drug trade names! Let go of your proteasome inhibitions, phenotype your red cells and let us modulate your understanding of what it is to treat myeloma with an alphabet soups worth of drugs. We sincerely apologise to our endocrinology colleagues for how much dexamethasone we use in this episode but also generally. Timestamps 4:00 - Overview of the treatment journey 9:49 - Steroids - not the bulking kind 13:54 - Immunomodulators - the IMiDs 19:46 - Proteasome inhibitors - Bortezomib, Carflizomib 24:45 - Monoclonal antibodies - Daratumumab, Elotuzumab 28:31 - SINE Inhibitor - Selinexor 29:27 - Antibody-drug conjugates - Belantamab mafodotin 30:27 - CELMoDs - Iberdomide, mezigdomide 31:06 - Standard chemotherapy 33:15 - Autologous stem cell transplant 38:21 - T-cell directed therapy - BiTes, CAR-T 40:57 - Supportive care Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 24 - Blue Fried Eggs | Intro to Multiple Myeloma 28:35

πριν 15 weeks28:35

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28:35

== I do not like blue eggs and ham, I do not like them, Sam I Am. They crowd and clump, they grow too fast, Causing troubles that can last. They make my bones feel weak and sore, And through my kidneys they gnaw! I do not like blue eggs, you see, They're signs of something wrong with me. == Timestamps 3:35 - Recap of MGUS + smouldering myeloma 4:42 - Clinical case - Mr. Peter Rotein 8:15 - What is rouleaux? 10:30 - Bone marrow biopsies - what, how, how much ow? 15:29 - Multiple myeloma 16:41 - CRAB Criteria 18:26 - SLiM Criteria 19:24 - Clinical presentations of myeloma 21:48 - Plasmacytomas 22:56 - Causes of myeloma? 24:45 - Prognosis Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 23 - Help I found a paraprotein | MGUS + The Spectrum of Plasma Cell Dyscrasias 31:48

πριν 16 weeks31:48

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Ordered something you shouldn’t have and accidentally found a paraprotein again? Shame on you, but now you have to do something with it. Maybe you were genuinely suspicious for myeloma. If incidentally discovered lab findings are leaving you smouldering, this is the episode for you! Join Nick, Cale and Bashar as they chat about the spectrum of plasma cell dyscrasias, and cover the precursor conditions MGUS and Smouldering Myeloma. Timestamps 2:53 - What is a paraprotein? 5:56 - The heavy chain component 9:40 - The spectrum of plasma cell disorders 10:12 - MGUS 11:33 - How common is MGUS? 15:24 - You've found a paraprotein - what next? 17:38 - IMWG MGUS Criteria 19:47 - Mayo Score for Risk Stratification 22:25 - Serum free light chain ratio 24:25 - Bence Jones proteins 26:21 - Smouldering myeloma 27:30 - IMWG Smouldering myeloma criteria 29:16 - Risk of progression to MM Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 22 - B is for B-Cell | Immunology 101 35:24

πριν 17 weeks35:24

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35:24

A is for Antibody. B is for B-cell. C is for Cryoglobul… wait no we’ve covered that already. If you struggle to tell your thymus from an isthmus, can’t see the humour in humoural immunity and think a bursa is just some fancy elbow cushion then THIS is the episode for you. Join the Bloody Minded Crew as they dust off their undergraduate immunology degrees, get back to the classroom and cover the foundations of the immune system in preparation for tackling our upcoming malignant diseases. Timestamps 3:43 - The Immune System 4:50 - The Spleen 5:36 - The Thymus 6:19 - The Lymph Nodes 8:19 - The Innate Immune System 13:16 - The Adaptive Immune System 16:56 - VDJ recombination 21:21 - MHC/HLA 24:54 - Antibodies! 27:42 - Class switching 28:58 - The purpose of Plasma Cells 30:33 - An immune response - start to finish Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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Episode 21 - On the Wards: Welcome to the Jungle | Your First Haem Ward Round 44:54

πριν 19 weeks44:54

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44:54

Help! After a disastrous 3 way ward swap you now have to cover the haem ward as an intern in... 45 minutes time. If only there were some way you could get a crash course on everything you might need to know. Well are you in luck today! Join our new guest host Dr Alison Chandler for a whole new subtype of episodes, our new "On the Wards" series. “ These are for those new interns and residents who have been drafted to cover the dreaded haem wards and need to prepare all the practical day to day things. On this inaugural On The Wards episode we'll cover the haematology ward round, how to read a haematology note and plan for some planned admissions. Keep an eye out for these every so often in between our conventional topics. Timestamps 1:09 - Who is Dr Alison Chandler? 3:43 - What makes haem scary? 8:20 - Three top tips for haem JMOs 14:34 - The haem ward round - letters and numbers! 27:50 - Always look at the blood count 34:08 - Planned admissions 38:02 - Extra things to do on haem Check out show notes, additional references and (sometimes) extra content at www.bloodyminded.com.au…

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