OncoPharm is a podcast dedicated to all things oncology pharmacy. Most episodes cover updates and recent publications concerning the use of medications in caring for patients with cancer. Periodically, episodes drop devoted to Landmark Clinical Trials in oncology and Fundamentals of Oncology Pharmacy.
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Interlace PODCAST, the first and only blog dedicated to the internationalization aspects of education and culture. Internationalization in education and culture is today a solid reality that positively counterbalances the many negative aspects of globalization. General information on hot topics will be completed by country specific specials, programs entirely dedicated to cooperation for development, concrete best practices and programmes going deeper in the world of higher education or culture.
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Desert Shepherdess - Interlacing Traditional and Modern Shepherding Lifestyles in the Arid Desert
Marissa - Shepherdess, Homemaker, Homesteader, Farmer, Wife and Mom
Are you hoping to add sheep to you farm someday? Are you overwhelmed with farm work of all the different animals and feeling burned out? Do you wish there was an easy animal who gave you meat, milk and fiber? Do you live in the hot, dry desert and notice your wool sheep are not thriving and are actually costing you more money? Does the thought of living far away from a veterinarian scare you because you feel you must have knowledge of one to give your sheep a good life? Do you want to learn ...
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Discussing two excellent articles from earlier this month.S1826: N-AVD vs. Bv-AVD (DOI: 10.1056/NEJMoa2405888)& INTERLACE: induction chemo prior to concurrent cisplatin/RT in locally advanced cervical cancer (DOI: https://doi.org/10.1016/S0140-6736(24)01438-7)Από τον John Bossaer
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A new PIK3Ca inhibitor is approved for breast cancer.Από τον John Bossaer
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Reviewing 3 recent AML publicationsDouble-Dauno (90 mg/m2 vs. 60 mg/m2): https://doi.org/10.1200/JCO.24.00235AML60+ Risk Stratification: https://doi.org/10.1200/JCO.23.02631Decitabine-Ven as bridge to Allo HSCT: https://doi.org/10.1016/S2352-3026(24)00241-2Από τον John Bossaer
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MSI-high/MMRd rectal cancer treatment guidelines are being re-written. A brief synopsis of why treatment guidelines are changing so quickly in this space.Also, listeners helped out in explaining the ribociclib storage & stability change. Hint: https://www.novartis.com/news/novartis-implements-manufacturing-adjustments-ribociclib-ensure-alignment-la…
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FDA has been busy the last week approving:-ribociclib x 3 years in high risk stage II & III breast cancer based on the NATALEE trial as well as a new storage requirement-osimertinib indefinitely following chemoradiation in stage III EGFR-mutated NSCLC-amivantamab + chemotherapy following progression on osimertinib (Mariposa-2)-a subcutaneous formul…
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Recapping just some of the notable data coming out of ESMO 2024:-Final OS results from Keynote-522 (perioperative pembrolizumab in TNBC)-AMBASSADOR (adjuvant pembrolizumab in bladder cancer) -NIAGRA (perioperative durvalumab in bladder cancer)-ADRIATIC (discussed on ASCO recap Pod, but publication now available)-LEANOX (impact of lean body mass adj…
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LMS04 final OS results are published for doxorubicin + trabectedin in Leiomyosarcoma. Plus, a natural experiment of what happens in small cell lung cancer during an IV etoposide shortage. Finally, a nice paper provides some examples of how oncology pharmacists can bridge the care gap between oncology and primary care.LMS04: https://www.nejm.org/doi…
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This is chapter 1 of a keynote address from summer 2024 on putting together the pieces of oncology pharmacy - with an emphasis on how our knowledge of drug dosing changes with time.Video/slides available at YouTube: https://youtu.be/1Oae8AV5Af4Από τον John Bossaer
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We all know we aren't supposed to make cross-trial comparisons, but it happens anyway. So, let's compare FLARUA2 (osimertinb + chemo) and the newly FDA-approved MARIPOSA regimen (lazertinib + amivantamab) to see what we can (and can't) take away from such a dangerous cross-trial comparison.Από τον John Bossaer
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A mixed bag of Phase III results for using olanzapine with moderately emegotenic chemotherapy (MEC).Inui, et al: https://doi.org/10.1200/JCO.24.00278Ostwal, et al: doi:10.1001/jamanetworkopen.2024.26076Από τον John Bossaer
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A new cellular therapy is approved for synovial sarcoma and the anticipated approval has occurred for the dual IDH1/IDH2 inhibitor, vorasidenib.Από τον John Bossaer
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FDA appears to change its stance on evaluating perioperative (adjuvant followed by neoadjuvant) ICI study designs in NSCLC.Also, a simple blood test is approved to detect colorectal cancer, but there are several limitations compared to colonoscopy.Από τον John Bossaer
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Did you know high-dose chemotherapy with autologous stem cel rescue was a "standard" breast cancer treatment ~30 years ago? This story involves changing practices based on Phase II data and outright clinical trial fraud, and retractions of publications.On-site review of Bezwoda study: https://doi.org/10.1016/S0140-6736(00)90024-2Oral History: https…
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Reflections from vacation on 1) How similar the chef training experience on The Bear mirrors some pharmacy residency training and 2) being a resource to family/friends with oncology questions.Από τον John Bossaer
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Running through recent updates on epcoritamab, adagrasib + cetuximab for colorectal cancer, endometrial cancer, adjuvant dabrafenib/trametinib melanoma follow-up data, and topical capsaicin for delayed CINV.Also, a brief travelogue on my inaugural trip to ATOPP (advanced topics for oncology pharmacy professionals) Summit.…
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The MARIPOSA study suggests there may be a new preferred first line regimen (amivantamab + lazertinib) for metastatic EGFR-mutated NSCLC, as this regimen improved PFS compared to osimertinib.Από τον John Bossaer
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An experimental regimen for DLBCL piques my interest.VenetoclaxibrutinibPrednisoneObinutuzumabRevlimid (lenalidomide)Link: https://www.nejm.org/doi/pdf/10.1056/NEJMoa2401532Από τον John Bossaer
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A new drug is approved for MDS. While some will likely benefit from this new agent, the more enticing news is that inhibiting telomerase may be an attractive target for many malignancies.Από τον John Bossaer
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Lots and lots of updates from the past weekend's ASCO annual meeting.1. ADRIATIC (consolidation durvalumab in limited stage SCLC)2. NADINA (neoadjuvant Nivo/Ipi in stage III melanoma)3. *NICHE-2 (neoadjuvant Nivo/Ipi in dMMR colon cancer)4. CheckMate 8HW (Nivo/Ipi in dMMR metastatic colon cancer)5. TRANSMET (liver transplantation in colon cancer wi…
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ASCO & ONS (along with pharmacist representation) released updated safety standards for preparing, administering, and monitoring chemotherapy. Look for a calendar invitation to review your site's policies soon.Link: https://doi.org/10.1200/OP.24.00216Από τον John Bossaer
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A new drug for small-cell lung cancer, a bispecific, targeting DLL3 on small-cell lung cancer and CD3 on T-cells is FDA approved. But, infigratinib's FDA approval for cholangiocarcinoma is withdrawn.Από τον John Bossaer
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QT interval prolongation is a common hurdle to taking care of cancer patients. We dive into what QT interval prolongation is, why it matters, risk factors, and prevention/management strategies.Από τον John Bossaer
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The non-Award Winning series of Landmarks in OncoPharm returns to discuss a Next Big Thing in NHL that wasn't any better than plain old CHOP.From April 1993, it's Pro-MACE-CytaBOMLink: https://www.nejm.org/doi/full/10.1056/NEJM199304083281404Από τον John Bossaer
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Tisotumab vedotin garners a regular FDA approval for metastatic cervical cancer with OS benefit data.A lingering question that demands a focused RCT: What is the optimal dose of methotrexate in primary CNS lymphoma? I'm glad I'm not the only one with this question: https://doi.org/10.1177/10781552231176754What, some BRAF mutations in colorectal can…
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Lots of recent updates to cover this week...1. Adjuvant pembrolizumab of RCC demonstrates OS improvement in NEJM publication (DOI: 10.1056/NEJMoa2312695)2. Yet adjuvant nivolumab did not demonstrate OS improvement in the adjuvant setting. There may be a few reasons for this (https://doi.org/10.1200/JCO.2024.42.4_suppl.LBA358)3. A cytokine-fusion pr…
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Arguably, the most anticipated release of 4/19/24Από τον John Bossaer
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What I learned (or relearned?) at HOPA's 2024 Annual Conference: updates in Neuro Oncology, fedratinib toxicity, and bispecific antibodies in multiple myeloma.Also, fam-trastuzumab deruxtecan (T-DXd) garnered a site-agnostic approval for HER2 amplified solid tumors.Finally, the ALINA study, adjuvant alectinib in ALK+ NSCLC, was published in this we…
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Tumor Lysis Syndrome (TLS) is a foundational topic for all oncology clinicians. We discuss the what, the why, prevention, and treatment.Από τον John Bossaer
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There are many ways to protect your flock! Alpaca, llama, donkeys, pigs, LGDs... what do you use? I go through my experience with each of these and the pros and cons of each. Sheep need protection, what will you decide on? The Desert Shepherdess Workbook is on sale! It is not only for the desert. There is so much to consider! Let me help you star o…
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Are you ready to start your sheep journey?? I break down the cost of getting started from the actual sheep to daily upkeep! This is a major consideration. Sheep are for the long run. My Workbook on Getting Started with Sheep is on SALE! Grab it while it's available at such a low price! https://stan.store/Desert_Shepherdess…
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Discussing four papers that caught our eyes from the last few weeks:Pazopanib vs. placebo following metastatectomy. Always concerning when placebo has an OS advantage.ECOG-ACRIN E2810: https://doi.org/10.1200/JCO.23.01544Gemcitabine vs. Gem + Paclitaxel (Taxol) in pancreatic cancer patients after FOLFIRINOX: https://doi.org/10.1200/JCO.23.00795An R…
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Gardening With Wool! You don’t have to know how to spin or felt, you don’t need to know how to make all these things from wool. You can simply add raw wool into your garden and reap the benefits! In todays episode, I talk about many great properties that wool bring to your soil and plants! I have been using it in my garden for a few years and my so…
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Ep. 8: Preparing From Lambing Season
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Lambing season is my favorite! New life. Fresh milk. I look forward to it all year but I would be lying if I told you it was always sunshine and rainbows. The best way to succeed is to be prepared. Here is what I keep in my lambing kit! Veterinarian and/or Mentor Number Jugs Heat Source Gloves Scissors Coconut Oil Halter/Lead Towel Digital Scale Pr…
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Do you want to simplify your farm using sheep? Let me help you defeat burnout! 5 Things to Consider for Sustainability Time Resorces Present Time Breed Minerald amd Vitamins Grab by Desert Shepherding Workbook to guide you to success with sheep! Don't miss it, it's ON SALE! Did you know you can now have a 1:1 Video Call with me to discuss your goal…
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Two recent publications suggest more people may be choosing non-colonoscopy screening practices in the future. One is a new stool DNA test, while the other is a blood test.How do they compare to the gold standard of colonoscopy?Cell-free DNA blood test: DOI: 10.1056/NEJMoa2304714Next generation stool DNA test: DOI: 10.1056/NEJMoa2310336…
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In this episode I share the top 5 purposes for sheep! *Pet *Wool *Meat *Market *Dairy What is the purpose of your sheep? Are you using your sheep to their full potential?? Sheep Milk Morning Drink *Sheep milk *Raw Egg *Chia Seeds *Turmeric *Cloves *Cinnamon *Honey Blend all together for a protein packed yummy drink that will keep you satisfied for …
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The Blackbelly Barbados are wonderful meat sheep! If you're looking for a disease and parasite resistant meat sheep that is regal and beautiful, Barbados may be your fit! IG: @desert.shepherdess FB: Desert Shepherdess https://stan.store/Desert_ShepherdessΑπό τον Marissa Chayil
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EV-302 is finally published, and you have to squint to find any major critiques. Enfortumab bedouin + pembrolizumab fully arrives as a standard 1st-line regimen of advanced urothelial cancer.Also, nivolumab gets a 1st-line FDA approval for urothelial carcinoma in conjunction with cisplatin + gemcitabine based on CHECKMATE-901.…
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When a concern arises, who will you go to for advice? In todays episode we will discuss some options for who to go to and the pros and cons of a veterinarian, a mentor or Facebook group. I am excited for this episode because this can save a life of a flock member! It can help you not be overwhelmed when trouble comes up. https://stan.store/Desert_S…
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In todays episode, we will talk about what it means to be a shepherd. Does it just mean owning sheep? There is so much that goes into being a true shepherd. We may not trek the wilderness with our sheep but we could still build a relationship with them. My workbook is on sale, still! Grab it at this price while you can! I will help you be confident…
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In todays episode, I am sharing the 5 reasons I decided to rebrand and relaunch my podcast! 1. Sheep are gaining popularity 2. I wanted an easier to find title 3. Focusing on what I know; the desert 4. Simplicity 5. I want you to have a positive experience with sheep You can find me on Instagram: @desert.shepherdess Facebook: Desert Shepherdess You…
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Specific breeds can save you money! Who doesn't want to lower their feed bill and over all cost? You can find me on: instagram: @ desert.shepherdess facebook: Desert Shepherdess Grab my FREE list of desert breeds and my Desert Shepherding Workbook! Start off on the right foot! https://stan.store/Desert_Shepherdess…
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My mission as the Desert Shepherdess is to help modern day shepherds attain healthy sheep based on where they are you what they have at the moment. I give tactical solutions to be frugal, using every bit of the sheep to the best of their ability. Sheep were the first domesticated animals, we can learn a thing or two about the old ways! We have beco…
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Two nice studies have been recently published in the supportive care realm.SPARED asks if we can omit dexamethasone on days 2-4 following cisplatin-based chemotherapy.D-TORCH asks if topical diclofenac can prevent capecitabine-induced hand-foot syndrome.SPARED: https://doi.org/10.1038/s41416-023-02493-7 D-TORCH: https://doi.org/10.1200/JCO.23.01730…
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An exciting new cellular therapy, lifileucel, is approved for metastatic melanoma. The FLAURA2 trial of osimertinib + chemotherapy has led to an FDA approval, but questions remain about a possible new standard of care. And a few minor updates on tepotinib.Από τον John Bossaer
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New updates on metastatic pancreatic cancer (NAPOLI-3), upper tract urothelial cancer (POUT), and the drug-drug interaction between ivosidenib and azole antifungals.NAPOLI 3: https://doi.org/10.1016/S0140-6736(23)01366-1POUT (final OS): https://doi.org/10.1200/JCO.23.01659Ivosidenib Azole Antifungal DDIs: https://doi.org/10.1002/cncr.35251…
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You know about small cell lung cancer, but let's talk about small cell carcinoma of the prostate.Από τον John Bossaer
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In oncology we are always asking questions about which treatment option is best. And that focus on the next best treatment may prevent us from rethinking some fundamentals of current practice. Three recent studies illustrate this and made me ask:Do we need a Port or PICC for every testicular cancer patient?Study: https://doi.org/10.1200/OP.23.00580…
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...on FDA approvals for belzutifan for RCC, pembrolizumab + cisplatin/RT for cervical cancer, erdafitinib (FGFR3 alterations only) for bladder cancer.Plus, early morning ICIs (https://doi.org/10.1016/j.ejca.2024.113571)&FLAG-Ida-GO in AML from NCRI AML 19 (https://doi.org/10.1200/JCO.23.00943)Από τον John Bossaer
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Special guest Ryan Beechinor joins the pod to discuss his recent paper on the obstacles in the development of generic lenalidomide. It's a fantastic read, and this episode will be a fantastic listen!Link: https://doi.org/10.1016/j.jcpo.2023.100446Από τον John Bossaer
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