Τα καλύτερα Genome podcast (2024)

1
S3 E5 - Amanda Pichini's journey to Clinical Director for Genomics England 42:48

4d ago42:48

42:48

In this episode, we come to you from Genomics England HQ in Canary Wharf, as Helen talks to Amanda Pichini, Clinical Director for Genomics England, and Genomic Counsellor. Amanda chats about her career journey so far, her work with Genomics England and the importance of Genetic Counselling. We also hear about exciting future projects that are comin…

1
Adopt-A-Genome 26:45

27d ago26:45

26:45

In this episode, undergraduates adopt genomes that the JGI sequenced, but never published in the literature. These students analyze the genomes, write reports, and publish first-author papers, making the data available for future research. Hear from Rekha Seshadri (JGI) and Matt Escobar (California State San Marcos) about how the Adopt-A-Genome pro…

1
S3 E4 - Building Support, Finding Stability, and Hitting the Inchstones. CRELD1 - pt2 38:22

18d ago38:22

38:22

This week we're back once again with Adam Clatworthy, from the heart of Guys Hospital, London, supported by the South East Genomic Medicine Service Alliance. In part 2 of Adam's journey, Helen talks to Adam C about his family's diagnostic odyssey that eventually saw 2 of his children diagnosed with the rare disease, CRELD1. We learn more about the …

1
S3 E3 - One Family's Rare Disease Odyssey - CRELD1, Pt1 30:01

1M ago30:01

30:01

This week we come to you from the heart of Guys Hospital, London, supported by the South East Genomic Medicine Service Alliance. In the first part of this 2-part episode, Helen talks to Adam Clatworthy about his family's diagnostic odyssey that eventually saw 2 of his children diagnosed with the rare disease, CRELD1. Sharing the reality of their jo…

1
S3 E2 - Pharmacogenomics with Emma Groves 41:31

2M ago41:31

41:31

On this episode, our host Helen Bethell talks all things Pharmacogenomics with Emma Groves, pharmacy lead for the North East & Yorkshire Genomic Medicine Service. Her interest in genomics was sparked by an online teaching session on monogenic diabetes, and ever since then Emma has been fascinated by the potential of genomics. Emma tells us about th…

1
S3 E1 - The Power of an Answer: Leukodystrophy with Dr. Lydia Green 46:34

2M ago46:34

46:34

On the first episode of season 3, our host Helen Bethell talks to Dr Lydia Green, a leading expert in the field of Leukodystrophies, or Inherited White Matter Disorders (IWMD) which affect the transmission of nervous impulses throughout the body, negatively impacting patients’ development, communication, cognitive and motor skills. Lydia tells us a…

1
Gotta Catch 'Em Gall 24:31

3M ago24:31

24:31

Kasey Markel and Patrick Shih (UC Berkeley and the Joint BioEnergy Institute) are looking for new ways to engineer plants. So they’ve looked into wasps that program oak trees to grow structures called galls. In this episode, hear from Kasey and Patrick about how this project unfolded, and how they worked with the JGI's metabolomics program to find …

1
S2 E6 - Bringing Genomics into Mainstream Nursing 27:07

4M ago27:07

27:07

On the final episode of Season 2 of The Road to Genome, Helen speaks to Karen Westaway, Lynch Syndrome Project Manager for the West Yorkshire & Harrogate Cancer Alliance. Karen tells us about her journey into Nursing, her amazing work as one of the Lynch Syndrome Nurse Educators with the NEY GMS, and where she is now.…

1
S2 E5 - Following the Genomics Dream, with Nurse Director Gill Moss. 28:07

4M ago28:07

28:07

On this episode of The Road to Genome, Helen chats to Gill Moss, Nurse Director for the North East & Yorkshire Genomic Medicine Service. Some of Gill's earliest memories are of her desire for nursing, and as she says herself, Gill has "quite literally followed her dream". Gill works to embed genomics into nursing & midwifery pathways, and raise awa…

1
A Redesign for Yeast’s Genome, Chromosome by Chromosome - Jef Boeke, Weimin Zhang & Leslie Mitchell 20:53

4M ago20:53

20:53

To engineer yeast to do more, and understand genomes in general, Jef Boeke, Weimin Zhang (NYU Langone Health) and Leslie Mitchell (Neochromosome) have worked to replace yeast’s native chromosomes with synthetic versions. This project has turned out to be an international collaboration, with some artistic endeavors along the way. Eventually, the goa…

1
S2 E4 - The Accidental Geneticist - The Journey of Paul Roberts, Lead Solid Cancer Scientist 32:49

5M ago32:49

32:49

On this episode of The Road to Genome, Helen uncovers the twists and turns of Paul Roberts' journey into genomics. From a planned career of teaching, to becoming the Lead Solid Cancer Scientist for the NEY GMS, Paul's route into genomics is, like many, full of twists and turns!Από τον North East & Yorkshire Genomic Medicine Service

1
Forest Fungi, Seagrass, and a New View of Symbiosis 26:34

5M ago26:34

26:34

Three stories of JGI-supported research, connected to nutrient cycles. Francis Martin and Lucas Auer discuss their work on communities of forest floor fungi. Allison Joy looks into seagrass meadows' carbon sequestration with insights from Adam Healey and Xiao Ma. And Karen Serrano and Benjamin Cole explain their research on the symbiotic relationsh…

1
Colloque - Emmanuelle Rial-Sebbag : Modèles embryonnaires : quelles conditions juridiques pour leur usage en recherche ? 46:09

5M ago46:09

46:09

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Emmanuelle Rial-Sebbag : Modèles embryonnaires : quelles conditions juridiques pour leur usage en recherche ? Intervenant(s) Emmanuelle Rial-Sebbag CERPOP, Inserm, Université Paul Sabatier, ToulouseΑπό τον Denis Duboule

1
Colloque - Jean-François Guérin : Quel statut éthique pour les modèles embryonnaires (embryoïdes) humains ? 42:25

5M ago42:25

42:25

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Jean-François Guérin : Quel statut éthique pour les modèles embryonnaires (embryoïdes) humains ? Intervenant(s) Jean-François Guérin Conseil d'orientation de l'Agence de la Biomédecine, LyonΑπό τον Denis Duboule

1
Colloque - Nicolas Rivron : Pourquoi diable et comment forme-t-on des modèles d'embryons humains en laboratoire ? 37:12

5M ago37:12

37:12

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Nicolas Rivron : Pourquoi diable et comment forme-t-on des modèles d'embryons humains en laboratoire ? Intervenant(s) Nicolas Rivron IMBA, Vienne AutricheΑπό τον Denis Duboule

1
Colloque - Alain Chédotal : Un atlas cellulaire pour cartographier l'embryon humain en 4 dimensions 40:19

5M ago40:19

40:19

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Alain Chédotal : Un atlas cellulaire pour cartographier l'embryon humain en 4 dimensions Intervenant(s) Alain Chédotal Institut de la vision, Paris, et MeLIS LyonΑπό τον Denis Duboule

1
Colloque - Fabriquer et cultiver des « embryons » in vitro : un état des lieux, cadres éthique et légal : Introduction 4:51

5M ago4:51

4:51

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Fabriquer et cultiver des « embryons » in vitro : un état des lieux, cadres éthique et légal : Introduction Intervenant(s) Denis Duboule Professeur du Collège de FranceΑπό τον Denis Duboule

1
Colloque - Barbara Treutlein : Understanding Human Brain Development with Organoids and Single-Cell Analysis 47:08

5M ago47:08

47:08

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Barbara Treutlein : Understanding Human Brain Development with Organoids and Single-Cell Analysis Intervenant(s) Barbara Treutlein ETH, Zurich, SuisseΑπό τον Denis Duboule

1
Colloque - Jacob Hanna : Synthetic Ex Utero Embryogenesis: From Naive Stem Cell to Complete Embryo Models 44:30

5M ago44:30

44:30

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Jacob Hanna : Synthetic Ex Utero Embryogenesis: From Naive Stem Cell to Complete Embryo Models Intervenant(s) Jacob Hanna Weizmann Institute of Science, Rehovot IsraelΑπό τον Denis Duboule

1
Colloque - Alfonso Martinez-Arias : The Human Embryo: A Changing Perspective 58:57

5M ago58:57

58:57

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - Alfonso Martinez-Arias : The Human Embryo: A Changing Perspective Intervenant(s) Alfonso Martinez-Arias ICREA Universidad Pompeu Fabra, BarcelonaΑπό τον Denis Duboule

1
Colloque - The Making of "Embryos" in Vitro: State of the Art: Welcome 4:50

5M ago4:50

4:50

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 Colloque - The Making of "Embryos" in Vitro: State of the Art: Welcome Intervenant(s) Denis Duboule Professeur du Collège de FranceΑπό τον Denis Duboule

1
04 - La fabrique des « embryons » : Les pseudo-embryons « intégrés » de type SEM. Fabrication et potentiel futur 1:25:01

5M ago1:25:01

1:25:01

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 04 - La fabrique des « embryons » : Les pseudo-embryons « intégrés » de type SEM. Fabrication et potentiel futur Résumé Pseudo-embryons intégrés ; définition, caractérisation et comparaison souris/humains. Potentiel expérimental et quelques questions éthiques …

1
S2 E3 - The Genomics of Haemato-Oncology with Polly Talley 28:20

5M ago28:20

28:20

On this episode of The Road to Genome, Helen is joined by Polly Talley, the Haemato-Oncology (HaemOnc) Lead Scientist for the NEY Genomic Laboratory Hub, and Senior Scientific Advisor for HaemOnc with the NHS England Genomics Unit. Polly tells us about her journey into the world of genomics and how her career has developed, and continues to develop…

1
What Happens To a Rainforest When You Dial Up Drought? - Linnea Honeker and Malak Tfaily 22:53

5M ago22:53

22:53

Rainforests store a big fraction of all the carbon on Earth, and soil microbes play a key role in pulling that carbon out of the atmosphere. This episode, researchers take a look at what happens to that storage when a rainforest hits a drought. Tag along with their experiments in a fully enclosed, human-made ecosystem: Biosphere 2. Links from this …

1
03 - La fabrique des « embryons » : Les gastruloïdes humains ; un ersatz d'embryon incomplet mais pratique 1:25:26

5M ago1:25:26

1:25:26

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 03 - La fabrique des « embryons » : Les gastruloïdes humains ; un ersatz d'embryon incomplet mais pratique Résumé Les gastruloïdes ; définition, production, caractérisation et comparaisons souris/humains. Des gastruloïdes comme objets d'étude et comme tubes à …

1
02 - La fabrique des « embryons » : La culture d'embryons ex-utero et la fabrication de blastoïdes humains 1:22:06

6M ago1:22:06

1:22:06

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 02 - La fabrique des « embryons » : La culture d'embryons ex-utero et la fabrication de blastoïdes humains Résumé Quelques notions d'embryologie comparée, cellules ES et cellules iPS comme matériel de base pour fabriquer des pseudo-embryons. Culture d'embryons…

1
S2 E2 - A Nurse's Journey into Precision Medicine 20:50

6M ago20:50

20:50

On this episode of The Road to Genome, Helen chats to our Genomic Lead Nurse, Kay Cawthron, about her journey into genomics and her current work with the North East & Yorkshire Genomic Medicine Service. From a young age, Kay was inspired by nursing, and providing care to those who need it most. Join us to hear how Kay rose to her current position a…

1
01 - La fabrique des « embryons » : L'embryon humain est-il un embryon mammifère ? 1:23:59

6M ago1:23:59

1:23:59

Denis Duboule Collège de France Évolution du développement et des génomes Année 2023-2024 01 - La fabrique des « embryons » : L'embryon humain est-il un embryon mammifère ? Résumé Après une introduction générale au contenu du cours et à ses objectifs, quelques bases du développement des embryons humains seront discutées afin de faire ressortir les …

1
S2 E1 - The DNA of Midwifery: Genomics and Midwifery Practice 28:31

6M ago28:31

28:31

Celebrating 'International Day of the Midwife' on Sunday 5th May, our first episode of The Road to Genome season 2 features an interview with Lead Midwife for the North East & Yorkshire Genomic Medicine Service, Denise Barnes. Denise talks to us about the role of the midwife, and how genomics influences the care and treatment options of pregnant pe…

1
S1 E5 - Genes, Guidance, and the Role of the Genetic Counsellor 33:46

7M ago33:46

33:46

In the last episode of our first series, your host Helen Bethell is in conversation with…… herself! For one episode only, Helen turns the tables and hands the mic to Jack Darling, to interview the interviewer! As a Genetic Counsellor, Helen is quizzed from the patient perspective, shares the twists and turns of her own fascinating career in educati…

1
S1 E4 - Decoding Lynch syndrome, with Professor Sir John Burn 32:11

7M ago32:11

32:11

This week, Helen completes her interview with Professor Sir John Burn, focusing on his ground-breaking research and discoveries in the specialist field of Lynch Syndrome - one of the more common causes of inherited cancer, including bowel cancer and endometrial cancer. He also talks about the trials he has led over many years demonstrating the impo…

1
S1 E3 - Genomic Pioneers: In Conversation with Professor Sir John Burn 35:18

8M ago35:18

35:18

This week, your host Helen Bethell is in conversation with Professor Sir John Burn, who perhaps needs little introduction. Sir John is a colossus in the field of genomic medicine and research, and he reflects on his incredible medical and academic career to date. Tracking his fascinating journey from growing up in a pit village in County Durham thr…

1
S1 E2 - How Genomics Supports the Patient Journey 20:14

8M ago20:14

20:14

This week, Helen is in conversation with Consultant Clinical Geneticist, Dr Jackie Cook, who, during her 30 years or so in genomics, has seen it all, from small beginnings when genetic testing was very limited, through to the mapping of the first human genome and all the innovative advances in genomic medicine that followed, and the impact these ha…

1
S1 E1 - A Patient's Journey Through Genetic Testing 33:23

8M ago33:23

33:23

This week host Helen Bethell is in conversation with patient, Jack Darling who works in the communications team with the NEY GMS. But he's also a patient with a rare genetic heart condition. In this episode, Jack openly shares his own emotional journey - from undergoing genetic testing as a teenager, through to receiving his diagnosis and treatment…

1
The Megadata of Lake Mendota - Part 3: Boating Out to David Buoy 24:38

11M ago24:38

24:38

This is the third and final episode of our series on a giant metagenome assembly from Wisconsin’s Lake Mendota. In the last two episodes, we’ve covered the specialized software and supercomputers behind this project. But every part of this project depends on lakewater samples — so this episode is a look at how researchers get these specialized snap…

1
The Megadata of Lake Mendota - Part 2: Souped Up Computing 22:06

11M ago22:06

22:06

This series is the story of a giant metagenome assembly from Wisconsin’s Lake Mendota. In this episode: a look at the supercomputing that stitches together large datasets with the assembler program MetaHipMer2. Oak Ridge National Lab is home to two supercomputers — Summit and Frontier — that process terabytes of data with MetaHipMer2. And the Natio…

1
The Megadata of Lake Mendota - Part 1: Many, Many Mers 26:16

12M ago26:16

26:16

Lake Mendota sits right next to the University of Wisconsin, Madison. And Trina McMahon's lab has been sampling the microbes of that lake for over 20 years, to understand how the freshwater ecosystem works. So a few years ago, when they set out to analyze 500 metagenomes, it was the biggest project the JGI had ever put together. The next 3 episodes…

1
Experimenting with EcoFABs for Student Labs - Jill Bouchard & Ying Wang 22:15

12M ago22:15

22:15

To set up flexible, repeatable experiments on plants and microbes, Trent Northen’s group at Berkeley Lab created a fabricated ecosystem – an EcoFAB. These small plastic growth chambers let researchers around the world compare their work consistently. And EcoFABs also work well in the classroom. This episode, we visit Los Medanos College to see EcoF…

1
JGIota: A Surprise for Chloroflexota — The First Flagella! 8:26

1y ago8:26

8:26

To understand how organisms adapt to extreme environments, Marike Palmer and Brian Hedlund study organisms living in hot springs. Hear how their recent work revealed more about the history of the Chloroflexota phylum and a new way of moving: a tail-like flagella. Submit your own proposal to work with the JGI Join us at the 2023 JGI User Meeting Lin…

1
JGIota: A Tool to Find the Nomadic Genes that Help Microbes Adapt - geNomad 5:51

1y ago5:51

5:51

A quick snippet on Antonio Camargo and Simon Roux, a few of the JGI researchers behind software that finds plasmids and viruses within microbial genomes. As mobile genetic elements like viruses spread their DNA, they can affect how microbes cycle nutrients and adapt to climate change. Episode Transcript Publication: Camargo, A.P., et al. “Identific…

1
Methane Makers in Yosemite's Lakes - Mike Beman and Elisabet Perez Coronel 27:16

1+ y ago27:16

27:16

Meet researchers who have hiked, rafted and met local wildlife (a marmot!) as they’ve sampled the microbial communities living in the mountaintop lakes of the Sierra Nevada mountains. These lakes are isolated, but varied. They’re a great way to see how climate change affects freshwater ecosystems, and how those ecosystems work. Links from this epis…

1
A Shrubbier Version of Rubber - Andrew Nelson and Colleen McMahan 20:37

1+ y ago20:37

20:37

Right now, our natural rubber comes from just one tree species: Hevea brasiliensis. It’s great at producing latex that becomes rubber, but it’s vulnerable to disease and climate shifts. So researchers are looking into a desert shrub that’s native to North America: guayule. This episode was made in collaboration with our friends at the HudsonAlpha I…

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 07 : Metabolic Control of Developmental Timing 41:59

1+ y ago41:59

41:59

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : Metabolic Control of Developmental Timing Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston). Intervenant(s) Olivier Pourquié, Harvard University, …

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 06 : Timing Mechanism Linking Development and Evolution of the Human Brain 38:13

1+ y ago38:13

38:13

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : Timing Mechanism Linking Development and Evolution of the Human Brain Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston). Intervenant(s) Pierre Van…

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 05 : About Time: The Dynamics of Neural Tube Development 32:58

1+ y ago32:58

32:58

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : About Time: The Dynamics of Neural Tube Development Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston). Intervenant(s) James Briscoe, Crick Institu…

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 04 : Temporal Patterning and Connectivity in the Nervous System 35:39

1+ y ago35:39

35:39

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : Temporal Patterning and Connectivity in the Nervous System Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston). Intervenant(s) Claude Desplan, NUY, …

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 03 : From Molecule Dynamics to Tissue Differentiation During Early Embryonic Development 33:40

1+ y ago33:40

33:40

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : From Molecule Dynamics to Tissue Differentiation During Early Embryonic Development Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston). Intervenant…

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 02 : Mechanics of Blastocyst Morphogenesis 30:39

1+ y ago30:39

30:39

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : Welcome Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston). Intervenant(s) Jean-Léon Maître, Curie Institute, Paris…

1
Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development 01 : Welcome 4:35

1+ y ago4:35

4:35

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 Colloque - Les temps du développement embryonnaire / The Times of Embryonic Development : Welcome Colloque co-organisé par le Pr Denis Duboule et Olivier Pourquié (Boston).Από τον Denis Duboule

1
05 - Les temps du développement embryonnaire 1:13:24

1+ y ago1:13:24

1:13:24

Denis Duboule Collège de France Évolution du développement et des génomes Année 2022-2023 05 - Les temps du développement embryonnaireΑπό τον Denis Duboule

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