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CAR T-cell therapy is an exciting new treatment for acute leukaemia. In this episode, Dr Geoff interviews his colleague Dr Caroline Bateman about CAR T-cells and introducing the treatment option to her unit. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.
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There is a special subtype of neuroblastoma seen in very young children, with spread of disease throughout the body, but which needs a very different approach to treatment compared to older children with metastatic disease. This episode explains the features of this stage MS neuroblastoma, the early problems, and the treatment used. Link to Patreon…
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Childhood cancer treatment leads to severe impairment of the ability to fight infections. This episode explains what immune suppression means, what causes it, and the problems that result. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.
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A few years ago I described CAR T-cells, but they weren't available for routine use. I now update things, with the very important news about CAR T-cell therapy now becoming available. There is also an interview with Dr Caroline Bateman re this subject in another episode. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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A number of countries have research studies where childhood cancers are analysed in great detail, testing all the DNA in something called 'molecular profiling'. The national Australian study of this is called PRISM, and it is a very exciting project. This episode explains a molecular profiling project and covers issues of obtaining informed consent…
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The MEK inhibitors are a newer class of drug, and include trametinib, selumetinib and others. They have an important role in paediatric oncology, particularly in glioma treatment and in neurofibromatosis. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.
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Sophisticated techniques can detect one cancer cell amongst a million normal cells. This episode describes these methods and how they are used in treatment. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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For many years we didn't biopsy the tumour when the scans suggested that the tumour was a DIPG. This episode explains why that has changed, and the emerging role of biopsy. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Ifosfamide is another chemotherapy drug, used particularly in certain sarcomas and certain patients with leukaemia. This episode explains how it is given, and common and rare side effects. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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At the American Society of Clinical Oncology meeting in June 2016, a study was presented looking at using two autologous bone marrow transplants in neuroblastoma. The results were exciting.... Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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In this episode I read out for you an article written by Dr Susan Cohn from the University of Chicago. Dr Cohn is an eminent paediatric oncologist, and a world expert on children's cancer trials, particularly in neuroblastoma. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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When families find themselves in a hospital, they meet all sorts of doctors with all sorts of titles, residents, interns, fellows, registrars. This episode explains who's who in the childhood cancer medical team. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Parents always ask why their child developed cancer. They ask if it is genetic, meaning is it something hereditary, or some abnormality in the DNA that the child was born with. In this episode I discuss a recent paper that examined this question. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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There are multiple ways to go looking for DNA, RNA and protein abnormalities. Many should still be considered research, not standard practice, but they may well be part of the future of cancer therapy. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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There's multiple ways the DNA code can get messed up and lead to cancer. This episode describes some of them, along with some little green men. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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The proteins have to have the right amino acids all assembled in the right order, and the DNA code is the recipe that's used. This episode explains how the correct DNA leads to the right protein being made. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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To understand all this DNA analysis business, first one needs to know a bit about proteins. Proteins basically do all the work in cells, and so DNA mutations interfere with protein structures.Serious geek alert! Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Some chemotherapy drugs don't get into the brain and spinal fluid properly, so we have to inject drugs into the spinal fluid. This is mainly in leukaemia and lymphoma. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Exciting new antibodies against cancer were reported at ASCO this year. This episode explains how they work. Will they end up useful in childhood cancer? Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Most new drugs for cancer are first evaluated in adult patients, then we wait, and wait for access for children. The Europeans appear to have this sorted out. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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High dose methotrexate is used in leukaemia, lymphoma, osteosarcoma and certain brain tumours. We give a sky-high dose, then give the antidote, folinic acid, to 'rescue' the patient! Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Platelets are tiny little cells that make blood clot properly. They go low after chemotherapy sometimes, and we often end up giving a platelet transfusion. That's one reason why blood donors save lives!This episode explains all about platelet transfusions. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.…
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We rely on central lines enormously, but they can bring their own problems. This episode describes the common things that can go wrong with a central line. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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We use phase 2 trials to conduct an initial evaluation of whether a new therapy has activity against cancer or leukaemia. This episode describes how phase 2 trials are performed. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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Clinical trials are core business in childhood cancer units. It is through clinical trials that we have worked out what treatments are effective, and future trials will lead to further gains. This episode describes what a clinical trial is, and introduces some of the key concepts. Link to Patreon Hosted on Acast. See acast.com/privacy for more info…
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Acute myeloid leukaemia is the second main form of leukaemia in childhood. This podcast explains what the disease is, and the tests and treatments done at initial diagnosis. Link to Patreon Hosted on Acast. See acast.com/privacy for more information.Από τον Dr Geoff
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