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Is Artemisinin Drug Resistance in Africa on the Rise?
Manage episode 386124463 series 3531530
Το περιεχόμενο παρέχεται από το Johns Hopkins Malaria Research Institute and Johns Hopkins Bloomberg School of Public Health. Όλο το περιεχόμενο podcast, συμπεριλαμβανομένων των επεισοδίων, των γραφικών και των περιγραφών podcast, μεταφορτώνεται και παρέχεται απευθείας από τον Johns Hopkins Malaria Research Institute and Johns Hopkins Bloomberg School of Public Health ή τον συνεργάτη της πλατφόρμας podcast. Εάν πιστεύετε ότι κάποιος χρησιμοποιεί το έργο σας που προστατεύεται από πνευματικά δικαιώματα χωρίς την άδειά σας, μπορείτε να ακολουθήσετε τη διαδικασία που περιγράφεται εδώ https://el.player.fm/legal.
Researchers examine the rise of artemisinin drug resistance in Eritrea - and search for its genetic basis.
Transcript
Artemisinin – a key antimalarial drug – and other drugs derived from it, are fast losing their effectiveness across South East Asia and increasingly in Africa, too. To investigate this, researchers conducted a review of drug efficacy studies in the East African country of Eritrea. They looked for the rates of delayed parasite clearance in the three days following treatment – a key marker of partial drug resistance. They found a troubling pattern: delayed parasite clearance climbed from 0.4% in 2016 to 1.9% in 2017, followed by a marked increase to 4.2% in 2019. By isolating and sequencing parasitic DNA, they found that this trend was associated with the rise of a novel mutation to the Kelch13 region of the parasite, called R622I. Given the lack of alternative drugs, the emergence of resistance in Africa is concerning.
Source
Increasing Prevalence of Artemisinin-Resistant HRP2-Negative Malaria in Eritrea
About The Podcast
The Johns Hopkins Malaria Minute podcast is produced by the Johns Hopkins Malaria Research Institute to highlight impactful malaria research and to share it with the global community.
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