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Think Twice: Even Bad Science Can Get Published!
Manage episode 447618435 series 3423865
Το περιεχόμενο παρέχεται από το BSM Partners. Όλο το περιεχόμενο podcast, συμπεριλαμβανομένων των επεισοδίων, των γραφικών και των περιγραφών podcast, μεταφορτώνεται και παρέχεται απευθείας από τον BSM Partners ή τον συνεργάτη της πλατφόρμας podcast. Εάν πιστεύετε ότι κάποιος χρησιμοποιεί το έργο σας που προστατεύεται από πνευματικά δικαιώματα χωρίς την άδειά σας, μπορείτε να ακολουθήσετε τη διαδικασία που περιγράφεται εδώ https://el.player.fm/legal.
Do you have trust issues? We do, too. There is a lot of research out there, both good and bad, and the difference between reliable and not-so-reliable research typically comes down to one thing—study design. Using recent real-world examples, like the first-ever retraction in JAVMA’s 180-year history, join us as we expose the critical differences between well-designed studies and those that fall short.
Related Episodes
Incidence episode: https://bsmpartners.net/barking-mad-podcast/a-mountain-or-a-molehill-what-science-really-says-about-the-incidence-of-dcm
Lit Review episode: https://bsmpartners.net/barking-mad-podcast/pawing-through-the-research-uncovering-the-fatal-flaws-of-DCM
Examples of Poorly Designed Research
More on the JAVMA retraction: https://www.petfoodprocessing.net/articles/18426-unraveling-the-copper-controversy
The Effects of Feeding Pulse-Based, Grain-Free, Diets on Digestibility, Glycemic Response, and Cardiovascular Health In Domestic Dogs: https://harvest.usask.ca/items/a96ed26b-7cb5-4179-8308-20f67e7a9ffa
Development of plasma and whole blood taurine reference ranges and identification of dietary features associated with taurine deficiency and dilated cardiomyopathy in golden retrievers: A prospective, observational study: https://pubmed.ncbi.nlm.nih.gov/32413894/ (Check out the Expression of Concern for this one: https://pmc.ncbi.nlm.nih.gov/articles/PMC7480844/)
Taurine deficiency and dilated cardiomyopathy in golden retrievers fed commercial diets: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0209112
Responses in randomised groups of healthy, adult Labrador retrievers fed grain-free diets with high legume inclusion for 30 days display commonalities with dogs with suspected dilated cardiomyopathy: https://bmcvetres.biomedcentral.com/articles/10.1186/s12917-022-03264-x
DCM Research by BSM Partners
Blood parameters research: https://onlinelibrary.wiley.com/doi/10.1111/jpn.13946
Incidence paper: https://www.frontiersin.org/articles/10.3389/fanim.2022.846227/full
Board-Invited Literature Review: https://academic.oup.com/jas/article/98/6/skaa155/5857674?login=false
Show Notes
00:00 – Welcome to the Episode
03:22 – Breaking Down the Research Pyramid
09:10 – Considering All the Factors (And Controlling for Them in Research)
10:00 – What is a Literature Review, and Why is it Important?
12:47 – The Peer-Review Process and Fatal Flaws
17:07 – The FDA’s Announcement: Biased Questions Led to Biased Answers
20:46 – FDA Saves Face in Subsequent Updates
23:18 – What Goes into a Well-Designed Study?
28:20 – Nothing is Impossible, Some Things Are Just Really Hard!
32:16 – Examples of Where Research Fell Flat
35:24 – Blood Parameters don’t Tell All
38:36 – Don’t Demonize Ingredients, Instead Study Nutrients
41:19 – Full Transparency: Potential Limitations in BSM Partners’ Research
44:17 – Conclusion and Farewell
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