Τα καλύτερα Science & Medicine podcast (2024)

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Episode 572: Preventing RSV Infections in Infants 25:29

11d ago25:29

25:29

In episode 572, James and Mike invite Samantha Moe back to the podcast to go over the evidence around the safety and effectiveness of the monoclonal antibodies used to reduce the risk of respiratory syncytial virus (RSV) infections in infants. We go over all the numbers for hospitalizations and death so you can make evidence-informed decisions. Sho…

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Where does your sense of self come from? A scientific look | Anil Ananthaswamy 12:49

20d ago12:49

12:49

Our memories and bodies give us clues about who we are, but what happens when this guidance shifts? In this mind-bending talk, science writer Anil Ananthaswamy shares how the experiences of "altered selves" -- resulting from schizophrenia, Alzheimer's, foreign limb syndrome or other conditions -- shed light on the constructed nature of identity. He…

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Episode 570: Statistics made simple and relevant – we promise – PART III 35:22

22d ago35:22

35:22

In episode 570, James and Mike finish their trilogy on statistics. We take what we discussed in the previous podcasts and go through a couple of examples that will hopefully solidify what all the terms and numbers really mean. Show Notes 1) Sensible Medicine Doing statistics can be difficult but understanding them can be fairly simple 2) Analysis o…

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Episode 569: Statistics made simple and relevant – we promise – PART II 30:13

1M ago30:13

30:13

In episode 569, James and Mike continue to go over what statistics really show – we focus on what inferential statistics can and cannot do, what a p value means and more importantly what it doesn’t mean. And yes we try to keep all this stat stuff on a realistic and practical level – easier said than done. Show Notes Sensible Medicine Doing statisti…

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Episode 568: Statistics made simple and relevant – we promise 27:30

1M ago27:30

27:30

In episode 568, James and Mike go over what statistics really show – and importantly what they don’t show. We go over the terms and nuances and hopefully put them all into a simple context. Statistics are not just in medicine – they are in much of what you do every day – so you really do need to understand them. Show Notes Sensible Medicine Doing s…

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Episode 567: Industry and Us and You 49:44

2M ago49:44

49:44

In episode 567, Mike and James revisit the old topic of industry influence on health care providers. We go over the issues, the nuances and some of the latest evidence around the interactions, the influence, and patient perceptions. Show Notes 1) Industry Evidence Handout 2) MAKING EVIDENCE MATTER for EVERYONE CONFERENCE Vancouver May 24/25, 2024 H…

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To RNase or Not to RNase: That Is the Question 14:05

2M ago14:05

14:05

Join Dr. Anna Wolska and Dr. Jim Posada as they delve into the intricacies of RNAse therapy in the management of Systemic Lupus Erythematosus (SLE). In this podcast episode, Dr. Posada describes the groundbreaking study evaluating the efficacy of RSLV-132, a novel RNAse molecule fused to human IgG1 Fc, in reducing chronic inflammation associated wi…

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A decision-aid facilitates patient understanding of benefits vs. risk of hydroxychloriquine use as part of routine care for lupus 15:05

3M ago15:05

15:05

Dr. Anna Wolska engages in a conversation with Dr. Shivani Garg and Dr. Christie Bartels to delve into the development and implementation of HCQ-SAFE. This innovative decision-aid is designed to empower individuals living with lupus to engage in shared-decision making. The authors discuss the importance of streamlining and enhancing shared decision…

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Episode 16: Maternal Mortality: A Modern Crisis: Part 3 - looking around the world to global solutions 18:43

4M ago18:43

18:43

In the US, every 12 hours a woman dies due to complications resulting from pregnancy. Additionally, 2 babies die each day. According to data from the national center for health statistics the maternal mortality rate for 2021 was 32.9 deaths per 100,000 live births, compared with a rate of 23.8 in 2020 and 20.1 in 2019 In 2021, the maternal mortalit…

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Episode 15: Maternal Mortality: A Modern Crisis: Part 2: Exploring Solutions 21:10

4M ago21:10

21:10

In the US, every 12 hours a woman dies due to complications resulting from pregnancy. Additionally, 2 babies die each day. According to data from the national center for health statistics the maternal mortality rate for 2021 was 32.9 deaths per 100,000 live births, compared with a rate of 23.8 in 2020 and 20.1 in 2019 In 2021, the maternal mortalit…

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Episode 14: Maternal Mortality - A Modern Crisis: Part 1 - Exploring the Problem 25:46

4M ago25:46

25:46

In the US, every 12 hours a woman dies due to complications resulting from pregnancy. Additionally, 2 babies die each day. According to data from the national center for health statistics the maternal mortality rate for 2021 was 32.9 deaths per 100,000 live births, compared with a rate of 23.8 in 2020 and 20.1 in 2019 In 2021, the maternal mortalit…

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Dual dsDNA testing may be needed to fully understand patient disease status 21:40

4M ago21:40

21:40

Dr. Anna Wolska speaks to Dr. Michael Belmont and Devyn Zaminski to discuss the importance of dual dsDNA testing in order to full understand disease activity. In this study, they made the observation that there is a large amount of discordance in anti-dsDNA antibodies assays. Misinterpretation or errors in anti- dsDNA antibody testing could have ne…

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WVU's Savannah Sims 41:46

5M ago41:46

41:46

The WISM podcast returns with one of WVU’s very own! Mallory chats with Dr. Savannah Sims, a graduate of the Biomedical Sciences Ph.D. program. She’s a passionate advocate of STEM and directed her career towards that aim. Dr. Sims relates inspiring and practical advice around finding your passion as a scientist, pushing against your comfort barrier…

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Is Anifrolumab an effective treatment for lupus nephritis? 12:44

5M ago12:44

12:44

Dr. Anna Wolska engages in a discussion with renowned experts, Dr. Catharina Lindholm and Dr. David Jayne, to explore findings from the phase II TULIP Lupus Nephritis trial. This in-depth conversation centers on results from a clinical trial where they evaluated the efficacy of intensified anifrolumab treatment in individuals with active lupus neph…

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Which one is better at controlling lupus: Belimumab or Anifrolumab? 12:38

6M ago12:38

12:38

Dr. Anna Wolska sits down with experts, Dr. Michelle Petri and Dr. Nick Ballew, analyzing the effectiveness of SLE treatments Belimumab and Anifrolumab. The conversation delves into their meticulous study, where they examined the 52-week SLE Responder Index (SRI)-4 responses, providing crucial data for informed lupus patient care. The study data, b…

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Managing Lupus Nephritis: Importance of Immunosuppression and Mitigation of Tissue Fibrosis 23:27

7M ago23:27

23:27

Dr. Anna Wolska from the Lupus Foundation of America interviews Drs. Ana Malvar and Brad Rovin. They discuss using repeat tissue biopsies to understand progression of lupus nephritis over time. They offer conjecture that both immunosuppression as well as mitigation of tissue fibrosis, resulting from inflammatory resolution, are needed in order to p…

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10. "Passing the Mic: A New Chapter Begins" - Jake Muldoon, Phd 29:20

7M ago29:20

29:20

The podcast takes an exciting turn as Jake Muldoon, the seasoned host, graciously hands over the microphone to the new host, Peter Samuel. With a blend of excitement and nostalgia, listeners are invited to witness this pivotal moment as the torch is passed. Join us as we bid farewell to Jake's tenure and warmly welcome Peter to the hosting seat. Th…

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Testing a new measure of lupus improvement that encompasses the patients’ perspectives and doctors’ evaluations 18:05

8M ago18:05

18:05

Dr. Anna Wolska from the Lupus Foundation of America interviews Drs. Anca Askanase and Joan Merrill, the developers of the LFA-REAL tool. Together, they discuss the importance of using a tool like LFA-REAL to understand how clinician and patient reported outcomes are essential for understanding efficacy and effectiveness of experimental therapeutic…

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Understanding Lupus: Exploring the Differences between Type 1 and Type 2 Symptoms 20:25

9M ago20:25

20:25

Dr. Anna Wolska from the Lupus Foundation of America interviews Dr. Amrie Grammer and Dr. Peter Lipsky from AMPEL BioSolutions. Together they describe the molecular endotypes of Type 1 and Type 2 Systemic Lupus Erythematosus. This episode uncovers the distinct molecular profiles of these SLE types and paves the way for personalized treatment approa…

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Xenotransplantation and Regenerative Medicine 30:14

10M ago30:14

30:14

What if we could replace diseased or damaged organs and other body parts with new lab-created versions? How might transplanting tissue from other species help the critical shortage of human transplant organs? Tune in to listen to two noted experts in regenerative therapeutics and xenotransplantation (transplanting organs between members of differen…

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9: "COVID and the Latino Community" - Dr. Ricardo Correa 33:55

10M ago33:55

33:55

The COVID pandemic has been catastrophic around the world. Within the United States there are communities harder hit than others. Dr. Ricardo Correa and his team have gone above and beyond the call to service for the latino community. Education is the answer to misinformation and building trust is key. He is an individual that lives up to our motto…

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6: "A Brighter Future for Cancer Research" Dr. William Oh 25:47

10M ago25:47

25:47

Without innovation the research field of medicine would fade away. Research is hard and at times can be crushing. Dr. William Oh is a pioneer for prostate cancer research and is optimistic about the future of the field. We discuss his contributions which have pushed our limits of understanding, but we also learn about who he is as a person and what…

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7. Monday Motivation: KEEP GOING 3:53

10M ago3:53

3:53

Those in the medical field can all agree, some days you just want to give up. Monday Motivations are to remind us of all the great things we can do, to never quit, and to KEEP GOING. Be Curious and Be Kind .Από τον Jake Muldoon, PhD (IJCR Central)

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5. "Nuclear Energy and Health: A Final Warning"- Dr. Robert Peter Gale 25:38

10M ago25:38

25:38

The KGB had a dossier on him, he attended the funeral for a Soviet Head of State, and as an American he was asked by the Soviet Union to coordinate medical relief to the Chernobyl nuclear disaster. The life of Dr. Robert Peter Gale sounds like it should be a movie, in fact his accounts at Chernobyl were made into a film, in which he was portrayed b…

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8. "If Only I Knew THIS Earlier"- Jake Muldoon, Phd (Monday Motivation) 6:14

10M ago6:14

6:14

The secret to life is simple but it is hard to carry out. As years tick by it can seem that opportunity escapes us. That couldn't be farther from the truth. The International Journal of Clinical Research has shown me that with the right people and proper state of well-being, that which seems impossible can be a reality. Who could've predicted the g…

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2: "Rising above Rejection"- Dr. Yusuf Rahman 22:50

10M ago22:50

22:50

Plan A didn't work out? Good...there are 25 more letters in the alphabet to work through. When facing rejection it is easy for us to freeze and give up. I speak today with Dr. Yusuf Rahman, who received the news that he did not match for a residency program. While devastating to hear, he persevered, kept a positive mental attitude, and found succes…

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4. "Surviving Chernobyl, Tackling COVID"- Dr. Yan Leyfman 28:19

10M ago28:19

28:19

Guest Dr. Yan Leyfman was a victim of the Chernobyl Nuclear Disaster, the overwhelming odds of survival that he and his family faced were unfathomable. Like so many others, he found himself an immigrant in Brooklyn, NY. When the COVID-19 pandemic wreaked havoc on his new found home he couldn’t stand by and watch. As part of the Global COVID-19 Task…

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3. "LGBTQ Love Yourself"- Patrick Wolfe 31:49

10M ago31:49

31:49

As we come to the end of Pride Month what does that even mean? It means we have brothers and sisters around the world with different sexual orientations who are no less deserving of Love than you or I. My guest Patrick Wolfe grew up in the Mormon religion, a branch of Christianity popular in the western United States. While living as a missionary h…

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1: "Our Mission Knows No Borders" Dr. Gregory Nicolas 27:22

10M ago27:22

27:22

An open access journal for clinical research?! A collaborative effort around the globe. We speak with Dr. Gregory Nicolas, the managing editor for IJCR (International Journal of Clinical Research). He shares his story on how an idea became a reality and continues to grow. Raised in Lebanon, now living in Brazil, his journey across the hemispheres l…

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Unpacking Lupus Treatment: How Quickly Does Anifrolumab Start Working? Insights from TULIP Trials 14:42

10M ago14:42

14:42

Dr. Anna Wolska from the Lupus Foundation of America interviews Dr. Ian Bruce, from the University of Manchester in the UK. Dr Bruce discusses the time to onset of clinical response to Anifrolumab in patients with Systemic Lupus Erythematosus. The episode delves into pooled data from two significant Phase III trials, TULIP-1 and TULIP-2, offering l…

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University of Kentucky's Carrie Shaffer 34:12

10M ago34:12

34:12

Mallory sits down with Dr. Carrie Shaffer, Assistant Professor in the Veterinary Science, Pharmaceutical Sciences, and Microbiology, Immunology and Molecular Genetics Departments at the University of Kentucky. They discuss her passionate pursuit of science from a very early age, some of the unique characteristics and duties of land grant institutio…

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Wearables and Digital Health 35:34

10M ago35:34

35:34

Wearable technology has come a long way from being a novelty. These wearables are now being used to help monitor patients to forestall problems. They can help people take a more active role in their health. Plus, the trove of data they collect can help medical researchers. Explore how wearables and digital health individualize medicine in this epis…

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Digital Health Enabled Genomics 36:31

11M ago36:31

36:31

Wearable technologies are becoming more and more popular. Add to the mix digital health apps and there's a trove of data being translated into meaningful health information for users, physicians and researchers. Explore the emergence of these digital tools in individualized medicine in this episode of Mayo Clinic's "The Pursuit of Precision: The Sc…

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Organoids: A Powerful Tool for Individualized Medicine Research 21:15

11M ago21:15

21:15

Organoids are like mini organs giving researchers new insights into human development and disease and could revolutionize fields like drug discovery. Researchers can develop a wide variety of organoids from the liver to the brain. Hear about the potential and limitations of using human organoids to bridge the gap between human and animal research. …

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Could we treat Alzheimer's with light and sound? | Li-Huei Tsai 12:45

11M ago12:45

12:45

What if we could use brain waves to treat Alzheimer's? Professor and neuroscientist Li-Huei Tsai details a promising new approach to artificially stimulate gamma brain waves using light and sound therapy, to increase connectivity and synchrony and delay the onset of this deadly disease. This non-invasive therapy has already been shown to work in mi…

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Are life-saving medicines hiding in the world's coldest places? | Normand Voyer 12:17

11M ago12:17

12:17

Could the next wonder drug be somewhere in Canada's snowy north? Take a trip to this beautiful, frigid landscape as chemist Normand Voyer explores the mysterious molecular treasures found in plants thriving in the cold. These scarcely investigated organisms could hold immense medical promise, he says – so long as we work quickly enough to discover …

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Are life-saving medicines hiding in the world's coldest places? | Normand Voyer 11:56

11M ago11:56

11:56

Could the next wonder drug be somewhere in Canada's snowy north? Take a trip to this beautiful, frigid landscape as chemist Normand Voyer explores the mysterious molecular treasures found in plants thriving in the cold. These scarcely investigated organisms could hold immense medical promise, he says – so long as we work quickly enough to discover …

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