Ep 9: Dave Feldman, Citizen Scientist—What Causes Heart Disease

Tucker Goodrich: Debugging Life

Dave Feldman and I discuss the what causes heart disease, specifically focusing on the consensus view and how it differs from what the science actually shows.

Youtube: https://youtu.be/amwNvHHmy4o

Rumble:

X:

Podcast:

Topics:

Basic theory of CVD causation:

· High ApoB/LDL/Cholesterol

· Gradient causes penetration of arterial wall

· Cholesterol/lipid oxidation in wall

· Progression through stages of atherosclerosis

· Blockage/rupture of plaque

· Ischemia of blood to heart

· Death/morbidity via MI

Electro-negative LDL

Aggregated LDL

TG-rich Lipoproteins

Risk and factor models

FH mortality—implications for causality

ApoB48

Albumin

Vasa vasorum

'Atherosclerosis' in veins

_______________________________________

Dave Feldman

Biography:

“I’m a senior software engineer and entrepreneur.

“I began a Low Carb, High Fat diet in April 2015 and have since learned everything I could about it with special emphasis on cholesterol given my lipid numbers spiked substantially after going on the diet. As an engineer, I spotted a pattern in the lipid system that’s very similar to distributed objects in networks.

“I’ve since learned quite a bit on the subject both through research and experimentation which has revealed some very powerful data. With this new general theory, I’ve shifted around my cholesterol substantially without any drugs or special supplements of any kind.

From: https://cholesterolcode.com/about/

Blog: https://cholesterolcode.com/

Twitter: https://twitter.com/realDaveFeldman

Citizen Science Foundation:

Site: https://citizensciencefoundation.org/

Twitter: https://twitter.com/realCSF

DONATE: https://citizensciencefoundation.org/donate/

Own Your Labs: https://ownyourlabs.com/

Tucker Goodrich

Blog: http://yelling-stop.blogspot.com/

Youtube: https://www.youtube.com/channel/UCDpWmYeRapRkrZ9zw8M7iFg

Podcast: https://sites.libsyn.com/408758

Twitter: https://twitter.com/TuckerGoodrich

Looking to fix your diet by getting rid of seed oils?

Check out the Seedy app!

https://www.seedyapp.com/

_______________________________________

Show Notes

Notes

See the canine LMHR study:

Kronfeld, D. S., Hammel, E. P., Ramberg, C. F., & Dunlap, H. L. (1977). Hematological and metabolic responses to training in racing sled dogs fed diets containing medium, low, or zero carbohydrate. The American Journal of Clinical Nutrition, 30(3), 419–430. https://doi.org/10.1093/ajcn/30.3.419

Lipid-Energy Model

Norwitz, N. G., Feldman, D., Soto-Mota, A., Kalayjian, T., & Ludwig, D. S. (2022). Elevated LDL Cholesterol with a Carbohydrate-Restricted Diet: Evidence for a “Lean Mass Hyper-Responder” Phenotype. Current Developments in Nutrition, 6(1), nzab144. https://doi.org/10.1093/cdn/nzab144

Norwitz, N. G., Soto-Mota, A., Kaplan, B., Ludwig, D. S., Budoff, M., Kontush, A., & Feldman, D. (2022). The Lipid Energy Model: Reimagining Lipoprotein Function in the Context of Carbohydrate-Restricted Diets. Metabolites, 12(5), Article 5. https://doi.org/10.3390/metabo12050460

PubMed for Dave's other papers:

https://pubmed.ncbi.nlm.nih.gov/?term=norwitz+feldman&sort=pubdate

Thoracic duct image:

Rosenblum, H., Kapur, N. K., Abraham, W. T., Udelson, J., Itkin, M., Uriel, N., Voors, A. A., & Burkhoff, D. (2020). Conceptual Considerations for Device-Based Therapy in Acute Decompensated Heart Failure: DRI 2 P 2 S. Circulation: Heart Failure, 13(4), e006731. https://doi.org/10.1161/CIRCHEARTFAILURE.119.006731

Lipoprotein lipase effect on heart:

Khan, R. S., Lin, Y., Hu, Y., Son, N.-H., Bharadwaj, K. G., Palacios, C., Chokshi, A., Ji, R., Yu, S., Homma, S., Schulze, P. C., Tian, R., & Goldberg, I. J. (2013). Rescue of Heart Lipoprotein Lipase-Knockout Mice Confirms a Role for Triglyceride in Optimal Heart Metabolism and Function. American Journal of Physiology-Endocrinology and Metabolism, 305(11), E1339–E1347. https://doi.org/10.1152/ajpendo.00349.2013

EAS Consensus:

Ference, B. A. et. al. (2017). Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 38(32), 2459–2472. https://doi.org/10.1093/eurheartj/ehx144

Borén, J. et. al. (2020). Low-density lipoproteins cause atherosclerotic cardiovascular disease: Pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel. European Heart Journal, 41(24), 2313–2330. https://doi.org/10.1093/eurheartj/ehz962

FH epidemiology:

Sijbrands, E. J. G. et. al. (2001). Mortality over two centuries in large pedigree with familial hypercholesterolaemia: Family tree mortality study. BMJ, 322(7293), 1019–1023. https://doi.org/10.1136/bmj.322.7293.1019

Is CVD Genetic?

Lee, K. T., Nail, R., Sherman, L. A., Milano, M., Lee, K. T., Deden, C., Imai, H., Goodale, F., Nam, S. C., Lee, K. T., Goodale, F., Scott, R. F., Snell, E. S., Lee, K. T., Daoud, A. S., Jarmolych, J., Jakovic, L., & Florentin, R. (1964). Geographic Pathology of Myocardial Infarction: Part I. Myocardial infarction in orientals and whites in the United States; Part II. Myocardial infarction in orientals in Korea and Japan; Part III. Myocardial infarction in Africans in Africa and negroes and whites in the United States; Part IV. Measurement of amount of coronary arteriosclerosis in Africans, Koreans, Japanese and New Yorkers. The American Journal of Cardiology, 13(1), 30–40. https://doi.org/10.1016/0002-9149(64)90219-X

Presentation on Rancidity in Seed Oils

AOCS American Oil Chemists’ Society (Director). (2021, April 1). Why Does Lipid Oxidation in Foods Continue to be Such a Challenge? [Mp4]. https://www.youtube.com/watch?v=B_U_9vvpDWo

Mercodia OxLDL Assay

Feldman, D. (2019, May 11). The Oxidized LDL Experiment [Informational]. Cholesterol Code. https://cholesterolcode.com/the-oxidized-ldl-experiment/

OxPL/ApoB test:

"Oxidized Phospholipids on apoB (OxPL-apoB)"

https://bostonheartdiagnostics.com/test/oxpl-apob-c-2/

Q's from X ( https://X.com ):

1. Eric Rodgers @LowCarbEyeDoc

ApoB48

2. Shashi Iyengar | Accredited Metabolic Health Coach @shashiiyengar

Touch up on palm oil Unprocessed and Refined deodorized one..

3. The Real Dr. Steven Horvitz @IMWHorvitz The difference between natural omega6 fats vs industrial processed omega6 fats.

4. MEATrition.com 🥩 @MEATritionCom

How does adipose %LA track with blood lipids?

5. MEATrition.com 🥩 @MEATritionCom

Specific ownyourlabs values to check for before and after removing seed oils from diet. What’s hypothesis?

6. TheFa(c)tHunter @DimitriRadoux

This might be an interesting one, the relationship of RDW and polyunsaturated fats 😉

7. joe @vintage_worlds

A few words on the ideal level of Linoleic acid as measured in rbc? Anyone set out to avoid seed oil while measuring their linoleic acid levels who have shown dramatic reductions by avoiding?

8. Michael J @astro_toaster

Fish oil and effects of supplementation on cholesterol? Supplements vs eating actual fish? 🤔

9. Luigi @Bac2us

Insulin resistance / consequences